缺氧诱导因子-1α在缺血性脑卒中模型中介导神经干-祖细胞作用机制的研究进展

doi:10.3969/j.issn.1006-9771.2017.03.015

Abstract

Abstract: Hypoxia inducible factor-1α is a kind of hypoxia response factor. Acute cerebral ischemia and anoxia can induce up-regulation of hypoxia inducible factor-1α, and the downstream genes, which plays a role in both the energy metabolism and collateral circulation after cerebral ischemia. Neural stem and progenitor cells regeneration also benefit the functional outcome after ischemic stroke. Hypoxia inducible factor-1α may induce proliferation and differentiation of neural stem and progenitor cells through Notch, Wnt/β-catenin pathways, etc., in the ischemic stroke model.

Key words: ischemic stroke, hypoxia inducible factor-1α, neural stem and progenitor cells, review

CLC Number:

R743.3

ZHANG Dong-yuan, LI Ming, WANG Zheng-ze, ZHANG Wen-ran, XU Xiao-dan, ZHANG Li- ying, TIAN Shen. Mechanism of Neural Stem and Progenitor Cells Mediated by Hypoxia Inducible Factor-1α in Ischemic Stroke Model (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(3): 319-322.

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Mechanism of Neural Stem and Progenitor Cells Mediated by Hypoxia Inducible Factor-1α in Ischemic Stroke Model (review)

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