阿尔茨海默病脑内小胶质细胞的极化状态及电针的影响研究进展

doi:10.3969/j.issn.1006-9771.2017.07.008

Abstract

Abstract: There are two phenotypes of microglia, M1 and M2. Microglia in M2 polarization may associate with the phagorytosis of beta-amyloid and inhibition of Tau hyperphosphorylation, as well as in other pathology. Electroacupuncture can impact the phenotypes of microglia, which may play a role in the treatment for Alzheimer's disease.

Key words: Alzheimer's disease, microglia, phenotypes, electroacupuncture, review

CLC Number:

R749.1

LI Long, LIU Wei-lin, WANG Zhi-fu, TAO Jing, CHEN Li-dian. Role of Microglia Polarization in Alzheimer's Disease and Association to Electroacupuncture (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(7): 779-782.

References

[1] Chouraki V, Seshadri S. Genetics of Alzheimer's disease [J]. Adv Genet, 2014, 87: 245-294.
[2] Tramutola A, Lanzillotta C, Perluigi M, et al. Oxidative stress, protein modification and Alzheimer disease [J]. Brain Res Bull, 2016. [Epub ahead of print].
[3] Herrera AC, Prince M, Knapp M, et al. World Alzheimer Report 2016: Improving Healthcare for People with Dementia. Coverage, Quality and Costs Now and in the Future [R]. London: Alzheimer's Disease International, 2016.
[4] Calsolaro V, Edison P. Neuroinflammation in Alzheimer's disease: Current evidence and future directions [J]. Alzheimers Dement, 2016, 12(6): 719-732.
[5] Fu R, Shen Q, Xu P, et al. Phagocytosis of microglia in the central nervous system diseases [J]. Mol Neurobiol, 2014, 49(3): 1422-1434.
[6] Ponomarev ED, Maresz K, Tan Y, et al. CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells [J]. J Neurosci, 2007, 27(40): 10714-10721.
[7] Kawanokuchi J, Shimizu K, Nitta A, et al. Production and functions of IL-17 in microglia [J]. J Neuroimmunol, 2008, 194(1-2): 54-61.
[8] Czeh M, Gressens P, Kaindl AM. The Yin and Yang of microglia [J]. Dev Neurosci, 2011, 33(3-4): 199-209.
[9] Tang Y, Le W. Differential roles of M1 and M2 microglia in neurodegenerative diseases [J]. Mol Neurobiol, 2016, 53(2): 1181-1194.
[10] Boche D, Cunningham C, Docagne F, et al. TGFbeta1 regulates the inflammatory response during chronic neurodegeneration [J]. Neurobiol Dis, 2006, 22(3): 638-650.
[11] Suh HS, Zhao ML, Derico L, et al. Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators [J]. J Neuroinflammation, 2013, 10(1): 37.
[12] Hoozemans JJ, Rozemuller AJ, van Haastert ES, et al. Neuroinflammation in Alzheimer's disease wanes with age [J]. J Neuroinflammation, 2011, 8(1): 171.
[13] Lee CY, Tse W, Smith JD, et al. Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels [J]. J Biol Chem, 2012, 287(3): 2032-2044.
[14] Mawuenyega KG, Sigurdson W, Ovod V, et al. Decreased clearance of CNS beta-amyloid in Alzheimer's disease [J]. Science, 2010, 330(6012): 1774.
[15] Lambertsen KL, Clausen BH, Babcock AA, et al. Microglia protect neurons against ischemia by synthesis of tumor necrosis factor [J]. J Neurosci, 2009, 29(5): 1319-1330.
[16] Yanagisawa D, Kitamura Y, Takata K, et al. Possible involvement of P2X7 receptor activation in microglial neuroprotection against focal cerebral ischemia in rats [J]. Biol Pharm Bull 2008, 31(6): 1121-1130.
[17] Lue LF, Kuo YM, Beach T, et al. Microglia activation and anti-inflammatory regulation in Alzheimer's disease [J]. Mol Neurobiol, 2010, 41(2): 115-128.
[18] Krabbe G, Halle A, Matyash V, et al. Functional impairment of microglia coincides with beta-amyloid deposition in mice with Alzheimer-like pathology [J]. PLoS One, 2013, 8(4): e60921.
[19] Kawahara K, Suenobu M, Yoshida A, et al. Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice [J]. Neuroscience, 2012, 207: 243.
[20] Weekman EM, Sudduth TL, Abner EL, et al. Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice [J]. J Neuroinflammation, 2014, 11: 127.
[21] Jiang T, Zhang YD, Chen Q, et al. TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice [J]. Neuropharmacology, 2016, 105: 196-206.
[22] Sheng JG, Mrak RE, Griffin WS. Glial-neuronal interactions in Alzheimer disease: progressive association of IL-1α+ microglia and S100β+ astrocytes with neurofibrillary tangle stages [J]. J Neuropathol Exp Neurol, 1997, 56(3): 285-290.
[23] Sheffield LG, Marquis JG, Berman NE. Regional distribution of cortical microglia parallels that of neurofibrillary tangles in Alzheimer's disease [J]. Neurosci Lett, 2000, 285(3): 165-168.
[24] Yoshiyama Y, Higuchi M, Zhang B, et al. Synapse loss and microglial activation precede tangles in a P301S Tauopathy mouse model [J]. Neuron, 2007, 53(3): 337-351.
[25] Morales I, Jiménez JM, Mancilla M, et al. Tau oligomers and fibrils induce activation of microglial cells [J]. J Alzheimers Dis, 2013, 37(4): 849-856.
[26] Zilka N, Kazmerova Z, Jadhav S, et al. Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways [J]. J Neuroinflammation, 2012, 9(1): 47.
[27] Bhaskar K, Konerth M, Kokikocochran ON, et al. Regulation of tau pathology by the microglial fractalkine receptor [J]. Neuron, 2010, 68(1): 19-31.
[28] Asai H, Ikezu S, Woodbury ME, et al. Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1 [J]. Am J Pathol, 2014, 184(3): 808-818.
[29] 左丽君,张巍. 神经免疫炎症与阿尔茨海默病[J]. 中华临床医师杂志(电子版), 2013, 7(14): 163-165.
[30] Kigerl KA, Gensel JC, Ankeny DP, et al. Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord [J]. J Neurosci, 2009, 29(43): 13435-13444.
[31] Huang KY. A systematic review and meta-analysis of acupuncture for improving learning and memory ability in animals [J]. BMC Complement Altern Med, 2016, 16(1): 297.
[32] Zhou J, Peng W, Xu M, et al. The effectiveness and safety of acupuncture for patients with Alzheimer disease: a systematic review and meta-analysis of randomized controlled trials [J]. Medicine (Baltimore), 2015, 94(22): e933.
[33] 陈吉祥,吴羽楠,郑雅媗,等. 电针百会穴对APP/PS1双转基因小鼠学习记忆及脑源性神经营养因子表达的影响[J]. 中国康复理论与实践, 2015, 21(6): 642-647.
[34] 吴羽楠,陈吉祥,陶静,等. 电针百会对APP/PS1转基因小鼠学习记忆能力及Tau蛋白磷酸化的影响[J]. 中国康复医学杂志, 2015, 30(5): 432-436.
[35] Liu W, Wang X, Yang S, et al. Electroacupunctre improves motor impairment via inhibition of microglia-mediated neuroinflammation in the sensorimotor cortex after ischemic stroke [J]. Life Sci, 2016, 151: 313-322.
[36] Chen Y, Zhou J, Li J, et al. Electroacupuncture pretreatment prevents cognitive impairment induced by limb ischemia-reperfusion via inhibition of microglial activation and attenuation of oxidative stress in rats [J]. Brain Res, 2012, 1432(1): 36-45.
[37] 楼志来,俞国尧. 电针对缺血再灌注大鼠脑内小胶质细胞活化的影响[J]. 湖南中医杂志, 2014, 30(11): 165-167.
[38] Han B, Lu Y, Zhao H, et al. Electroacupuncture modulated the inflammatory reaction in MCAO rats via inhibiting the TLR4/NF-κB signaling pathway in microglia [J]. Int J Clin Exp Pathol, 2015, 8(9): 11199-11205.
[39] Liang Y, Du JY, Qiu YJ, et al. Electroacupuncture attenuates spinal nerve ligation-induced microglial activation mediated by p38 mitogen-activated protein kinase [J]. Chin J Integr Med, 2016, 22(9): 704-713.
[40] Chen XM, Xu J, Song JG, et al. Electroacupuncture inhibits excessive interferon-γ evoked up-regulation of P2X4 receptor in spinal microglia in a CCI rat model for neuropathic pain [J]. Br J Anaesth, 2015, 114(1): 150-157.
[41] Tu W, Wang W, Xi H, et al. Regulation of neurotrophin-3 and interleukin-1β and inhibition of spinal glial activation contribute to the analgesic effect of electroacupuncture in chronic neuropathic pain states of rats [J]. Evid Based Complement Alternat Med, 2015, 2015: 642081.

Role of Microglia Polarization in Alzheimer's Disease and Association to Electroacupuncture (review)

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