神经肌肉电刺激对慢性阻塞性肺疾病患者骨骼肌的康复研究进展

doi:10.3969/j.issn.1006-9771.2018.04.007

Abstract

Abstract: Neuromuscular electrical stimulation (NMES) is one of the electrotherapy that exerts a low-frequency current over the targeted nerves and muscles to induce skeletal muscle contractions to treat skeletal muscle dysfunction in patients. As an alternative rehabilitation modality, NMES is essential for patients with chronic obstructive pulmonary disease (COPD) who are unable to participate in conventional rehabilitation program. NMES could effectively improve the skeletal muscle strength, endurance, exercise capacity and quality of life of the patients with COPD. It may be related to remodeling skeletal muscle structure, reducing oxidative stress in skeletal muscle, and improving balance of skeletal muscle protein metabolism.

Key words: chronic obstructive pulmonary disease, neuromuscular electrical stimulation, skeletal muscle, strength, endurance, exercise ability, quality of life, review

CLC Number:

R562.2

LIU Jing-xin, WU Wei-bing, LIU Xiao-dan, HU Jun, YAN Jun-tao. Advance in Neuromuscular Electrical Stimulation on Skeletal Muscle in Patients with Chronic Obstructive Pulmonary Disease (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(4): 410-415.

References

[1] Murray CJ, Atkinson C, Bhalla K, et al.The state of US health, 1990-2010: burden of diseases, injuries, and risk factors[J]. JAMA, 2013, 310(6): 591-608.
[2] Lozano R, Naghavi M, Foreman K, et al.Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010[J]. Lancet, 2012, 380(9859): 2095-2128.
[3] Zhou M, Wang H, Zhu J, et al.Cause-specific mortality for 240 causes in China during 1990-2013: a systematic subnational analysis for the Global Burden of Disease Study 2013[J]. Lancet, 2015, 387(10015): 251-272.
[4] De Brandt J, Spruit MA, Derave W, et al.Changes in structural and metabolic muscle characteristics following exercise-based interventions in patients with COPD: a systematic review[J]. Expert Rev Respir Med, 2016, 10(5):521-545.
[5] Nyberg A, Carvalho J, Bui KL, et al.Adaptations in limb muscle function following pulmonary rehabilitation in patients with COPD - a review[J]. Rev Port Pneumol, 2016, 22(6):342-350.
[6] Giavedoni S, Deans A, Mccaughey P, et al.Neuromuscular electrical stimulation prevents muscle function deterioration in exacerbated COPD: a pilot study[J]. Respir Med, 2012, 106(10): 1429-1434.
[7] Vilaro J, Ramirez-sarmiento A, Martinez-Llorens JM, et al. Global muscle dysfunction as a risk factor of readmission to hospital due to COPD exacerbations[J]. Respir Med, 2010, 104(12): 1896-1902.
[8] Lepley LK, Wojtys EM, Palmieri-smith RM. Combination of eccentric exercise and neuromuscular electrical stimulation to improve biomechanical limb symmetry after anterior cruciate ligament reconstruction[J]. Clin Biomech, 2015, 30(7): 738-747.
[9] Durigan JL, Peviani SM, Delfino GB, et al.Neuromuscular electrical stimulation induces beneficial adaptations in the extracellular matrix of quadriceps muscle after anterior cruciate ligament transection of rats[J]. Am J Phys Med Rehabil, 2014, 93(11): 948-961.
[10] 杨永翠. 神经肌肉电刺激对脑卒中患者生活能力及肢体运动功能的影响[J]. 中国实用神经疾病杂志, 2015, 18(19): 112-113.
[11] 张月兰,李明,罗莎. 神经肌肉电刺激治疗脑卒中后吞咽功能障碍的疗效观察[J]. 中国实用神经疾病杂志, 2015, 18(8): 65-66.
[12] 徐晓明,段隽丹,杨麟. 神经肌肉电刺激与酸性刺激治疗急性脑卒中吞咽障碍口腔期的效果[J]. 中国康复理论与实践, 2017, 23(2): 194-198.
[13] 朱士文,江平胤,党红梅,等. 神经肌肉电刺激和吞咽训练对脑卒中后吞咽障碍的影响[J]. 中国康复理论与实践, 2011, 17(8): 730-732.
[14] Napolis LM, Dal Corso S, Neder JA, et al.Neuromuscular electrical stimulation improves exercise tolerance in chronic obstructive pulmonary disease patients with better preserved fat-free mass[J]. Clinics, 2011, 66(3): 401-406.
[15] Kaymaz D, Ergun P, Demirci E, et al.Comparison of the effects of neuromuscular electrical stimulation and endurance training in patients with severe chronic obstructive pulmonary disease[J]. Tuberk Toraks, 2015, 63(1): 1-7.
[16] Tasdemir F, Inal-Ince D, Ergun P, et al.Neuromuscular electrical stimulation as an adjunct to endurance and resistance training during pulmonary rehabilitation in stable chronic obstructive pulmonary disease[J]. Expert Rev Respir Med, 2015, 9(4): 493-502.
[17] 丁晓伟,王淑萍,黄英,等. 神经肌肉电刺激疗法的临床应用[J]. 沈阳医学院学报, 2014, 16(4): 234-236.
[18] 赵少珩,赵睿,张航,等.神经肌肉电刺激在周围神经损伤修复中的研究进展[J]. 医学综述, 2014, 20(14): 2586-2588.
[19] Sillen MJ, Franssen FM, Vaes AW, et al.Metabolic load during strength training or NMES in individuals with COPD: results from the DICES trial[J]. BMC Pulm Med, 2014, 14(1): 1-9.
[20] Azevedo Dde P, Medeiros WM, de Freitas FF, et al. High oxygen extraction and slow recovery of muscle deoxygenation kinetics after neuromuscular electrical stimulation in COPD patients[J]. Eur J Appl Physiol, 2016, 116(10): 1899-1910.
[21] Sillen MJ, Franssen FM, Delbressine JM, et al.Efficacy of lower-limb muscle training modalities in severely dyspnoeic individuals with COPD and quadriceps muscle weakness: results from the Dices trial[J]. Thorax, 2014, 69(6): 525-531.
[22] Vieira PJ, Chiappa AM, Cipriano G Jr, et al.Neuromuscular electrical stimulation improves clinical and physiological function in COPD patients[J]. Respir Med, 2014, 108(4): 609-620.
[23] Vivodtzev I, Rivard B, Gagnon P, et al.Tolerance and physiological correlates of neuromuscular electrical stimulation in COPD: a pilot study[J]. PLoS One, 2014, 9(5): e94850.
[24] Coquart JB, Grosbois JM, Olivier C, et al.Home-based neuromuscular electrical stimulation improves exercise tolerance and health-related quality of life in patients with COPD[J]. Int J Chron Obstruct Pulmon Dis, 2016, 11(1):1189-1197.
[25] Maddocks M, Nolan CM, Man WD, et al.Neuromuscular electrical stimulation to improve exercise capacity in patients with severe COPD: a randomised double-blind, placebo-controlled trial[J]. Lancet Respir Med, 2016, 4(1): 27-36.
[26] Sillen MJ, Wouters EF, Franssen FM, et al.Oxygen uptake, ventilation, and symptoms during low-frequency versus high-frequency NMES in COPD: a pilot study[J]. Lung, 2011, 189(1): 21-26.
[27] Sillen MJ, Janssen PP, Akkermans MA, et al.The metabolic response during resistance training and neuromuscular electrical stimulation (NMES) in patients with COPD, a pilot study[J]. Respir Med, 2008, 102(5): 786-789.
[28] Dal Corso S, Napolis L, Malaguti C, et al.Skeletal muscle structure and function in response to electrical stimulation in moderately impaired COPD patients[J]. Respir Med, 2007, 101(6): 1236-1243.
[29] Neder JA, Sword D, Ward SA, et al.Home based neuromuscular electrical stimulation as a new rehabilitative strategy for severely disabled patients with chronic obstructive pulmonary disease (COPD)[J]. Thorax, 2002, 57(4): 333-337.
[30] Marquis K, Debigare R, Lacasse Y, et al.Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease[J]. Am J Respir Crit Care Med, 2002, 166(6): 809-813.
[31] Kharbanda S, Ramakrishna A, Krishnan S.Prevalence of quadriceps muscle weakness in patients with COPD and its association with disease severity[J]. Int J Chron Obstruct Pulmon Dis, 2015, 10(1): 1727-1735.
[32] Abdellaoui A, Prefaut C, Gouzi F, et al.Skeletal muscle effects of electrostimulation after COPD exacerbation: a pilot study[J]. Eur Respir J, 2011, 38(4): 781-788.
[33] Vivodtzev I, Debigare R, Gagnon P, et al.Functional and muscular effects of neuromuscular electrical stimulation in patients with severe COPD: a randomized clinical trial[J]. Chest, 2012, 141(3): 716-725.
[34] Akar O, Gunay E, Ulasli SS, et al.Efficacy of neuromuscular electrical stimulation in patients with COPD followed in intensive care unit[J]. Clin Respir J, 2017,11(46):743-750.
[35] Vivodtzev I, Pepin JL, Vottero G, et al.Improvement in quadriceps strength and dyspnea in daily tasks after 1 month of electrical stimulation in severely deconditioned and malnourished COPD[J]. Chest, 2006, 129(6): 1540-1548.
[36] Rom O, Reznick AZ.The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass[J]. Free Radic Biol Med, 2016, 98: 218-230.
[37] Haegens A, Schols AM, Gorissen SH, et al.NF-kappaB activation and polyubiquitin conjugation are required for pulmonary inflammation-induced diaphragm atrophy[J]. Am J Physiol Lung Cell Mol Physiol, 2012, 302(1): L103-L110.
[38] Langen RC, Gosker HR, Remels AH, et al.Triggers and mechanisms of skeletal muscle wasting in chronic obstructive pulmonary disease[J]. Int J Biochem Cell Biol, 2013, 45(10): 2245-2256.
[39] Doucet M, Russell AP, Leger B, et al.Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease[J]. Am J Respir Crit Care Med, 2007, 176(3): 261-269.
[40] Pan LL, Ke JQ, Zhao CC, et al.Electrical stimulation improves rat muscle dysfunction caused by chronic intermittent hypoxia-hypercapnia via regulation of miRNA-related signaling pathways[J]. PLoS One, 2016, 11(3): e0152525.
[41] Gyanqpuig-Vilanova E, Rodriguez DA, Lloreta J, et al.Oxidative stress, redox signaling pathways, and autophagy in cachectic muscles of male patients with advanced COPD and lung cancer[J]. Free Radic Biol Med, 2015, 79: 91-108.
[42] Pomies P, Blaquiere M, Maury J, et al.Involvement of the FoxO1/MuRF1/Atrogin-1 signaling pathway in the oxidative stress-induced atrophy of cultured chronic obstructive pulmonary disease myotubes[J]. PLoS One, 2016, 11(8): e0160092.

Advance in Neuromuscular Electrical Stimulation on Skeletal Muscle in Patients with Chronic Obstructive Pulmonary Disease (review)

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