电针对APP/PS1小鼠脑功能活动影响的功能性磁共振成像研究

doi:10.3969/j.issn.1006-9771.2020.05.010

Abstract

Abstract:

Objective To investigate the effects of electroacupuncture at Baihui (DU20) and Shenting (DU24) on brain function of APP/PS1 mice.Methods Sixteen 4-month-old APP/PS1 mice in the same litter were randomly divided into model group (n = 8) and electroacupuncture group (n = 8). Eight transgenic negative mice in the same litter were as control group. The electroacupuncture group accepted electroacupuncture at Baihui and Shenting for 16 weeks. They were assessed withObject Recognition Test before and after intervention, and observed under small animal functional magnetic resonance imaging with regional homogeneity (ReHo) analysis.Results Compared with the control group, the discrimination ratio decreased in the model group after intervention (P < 0.05), while it increased in the electroacupuncture group compared with that in the model group ( P < 0.05). Compared with the control group, ReHo of right basal forebrain and left hippocampus decreased in the model group before intervention. Compared with the control group, ReHo decreased in bilateral hippocampus group and increased in retrosplenial cortex in the model group after intervention; while it increased in bilateral hippocampus and motor cortex and decreased in anterior cingulate gyrus in the electroacupuncture group compared with that in the model group. Conclusion Electroacupuncture at Baihui and Shenting may delay the decline of learning and memory ability in Alzheimer's disease model mice, which may relate to the regulation of functional activities in hippocampus.

Key words: Alzheimer's disease, electroacupuncture, learning and memory, brain function, functional magnetic resonance imaging, mice

CLC Number:

R749.1

LI Le,HUANG Sheng,LI Long,ZHANG Jia-yong,JIN Ting-ting,ZHANG Yu-hao,ZHANG Bing-xue,YANG Min-guang,LIANG Sheng-xiang,WANG Zhi-fu,LIU Wei-lin,TAO Jing,CHEN Li-dian. Effects of Electroacupuncture on Brain Function of APP/PS1 Mice: A Functional Magnetic Resonance Imaging Study[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(5): 544-549.

Figures/Tables 5

References 25

[1]	Scheltens P, Blennow K, Breteler M M, et al. Alzheimer's disease[J]. Lancet, 2016, 388(10043):505-517. doi: 10.1016/S0140-6736(15)01124-1 pmid: 26921134
[2]	Gong N, Dibb R, Bulk M, et al. Imaging beta amyloid aggregation and iron accumulation in Alzheimer's disease using quantitative susceptibility mapping MRI[J]. Neuroimage, 2019, 191(1):176-185. doi: 10.1016/j.neuroimage.2019.02.019
[3]	Hall A, Throesch B, Buckingham S, et al. Tau-dependent Kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer's disease[J]. J Neurosci, 2015, 35(15):6221-6230. doi: 10.1523/JNEUROSCI.2552-14.2015
[4]	Mormino E, Smiljic A, Hayenga A, et al. Relationships between beta-amyloid and functional connectivity in different components of the default mode network in aging[J]. Cereb Cortex, 2011, 21(10):2399-2407. doi: 10.1093/cercor/bhr025
[5]	Buckner R, Snyder A, Shannon B, et al. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory[J]. J Neurosci, 2005, 25(34):7709-7717. doi: 10.1523/JNEUROSCI.2177-05.2005
[6]	Hickman R, Faustin A, Wisniewski T. Alzheimer disease and its growing epidemic: risk factors, biomarkers, and the urgent need for therapeutics[J]. Neurol Clin, 2016, 34(4):941-953. doi: 10.1016/j.ncl.2016.06.009
[7]	Jia Y, Zhang X, Yu J, et al. Acupuncture for patients with mild to moderate Alzheimer’s disease: a randomized controlled trial[J]. BMC Complement Altern Med, 2017, 556(17):1-8.
[8]	Zeng B, Salvage S, Jenner P. Effect and mechanism of acupuncture on Alzheimer's disease[J]. Int Rev Neurobiol, 2013, 111(1):181-195.
[9]	Liu W, Zhuo P, Li L, et al. Activation of brain glucose metabolism ameliorating cognitive impairment in APP/PS1 transgenic mice by electroacupuncture[J]. Free Radic Biol Med, 2017, 112(11):174-190.
[10]	李忠仁. 实验针灸学[M]. 北京: 中国中医药出版社, 2003: 327-329.
[11]	姚爱娜, 王轩, 董联玲, 等. 地黄饮子配合针刺百会穴治疗阿尔茨海默病疗效观察[J]. 世界中西医结合杂志, 2016, 11(5):667-670.
[12]	Liu F, Li Z, Jiang Y, et al. A meta-analysis of acupuncture use in the treatment of cognitive impairment after stroke[J]. J Altern Complement Med, 2014, 20(7):535-544. doi: 10.1089/acm.2013.0364
[13]	谷巍, 金晓仙, 张燕军, 等. 针刺治疗阿尔茨海默病临床观察[J]. 中国针灸, 2014, 34(12):1156-1160.
[14]	Cui S, Xu M, Huang J, et al. Cerebral responses to acupuncture at GV24 and bilateral GB13 in rat models of Alzheimer’s disease[J]. Behav Neurol, 2018, 2018(1):1-10.
[15]	Holcomb L, Gordon M, Jantzen P, et al. Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits[J]. Behav Genet, 1999, 29(3):177-185. pmid: 10547924
[16]	Mueller S, Temple V, Oh E, et al. Early androgen exposure modulates spatial cognition in congenital adrenal hyperplasia (CAH)[J]. Psychoneuroendocrinology, 2008, 33(7):973-980. doi: 10.1016/j.psyneuen.2008.04.005
[17]	Wang H, He J, Zhang R, et al. Sensorimotor gating and memory deficits in an APP/PS1 double transgenic mouse model of Alzheimer’s disease[J]. Behav Brain Res, 2012, 233(1):237-243. doi: 10.1016/j.bbr.2012.05.007
[18]	Florian C. CREB antisense oligodeoxynucleotide administration into the dorsal hippocampal CA3 region impairs long- but not short-term spatial memory in mice[J]. Learn Mem, 2006, 13(4):465-472. doi: 10.1101/lm.249306
[19]	Gammie S, Nelson R. cFos and pCREB activation and maternal aggression in mice[J]. Brain Res, 2001, 898(2):232-241. pmid: 11306009
[20]	Sailasuta N, Harris K, Tran T, et al. Minimally invasive biomarker confirms glial activation present in Alzheimer's disease: a preliminary study[J]. Neuropsych Dis Treat, 2011, 7(1):495-499.
[21]	Turnbull M, Zoran B, Coulson E. Acute down-regulation of BDNF signaling does not replicate exacerbated amyloid-β levels and cognitive impairment induced by cholinergic basal forebrain lesion[J]. Front Mol Neurosci, 2018, 51(11):1-13.
[22]	Qian L, Milne M, Shepheard S, et al. Removal of p75 neurotrophin receptor expression from cholinergic basal forebrain neurons reduces amyloid-β plaque deposition and cognitive impairment in aged APP/PS1 mice[J]. Mol Neurobiol, 2019, 56(7):4639-4652. doi: 10.1007/s12035-018-1404-2 pmid: 30374941
[23]	Clark R, Broadbent N, Squire L. Hippocampus and remote spatial memory in rats[J]. Hippocampus, 2005, 15(2):260-272. doi: 10.1002/(ISSN)1098-1063
[24]	Carmichael O, Xie J, Fletcher E, et al. Localized hippocampus measures are associated with Alzheimer pathology and cognition independent of total hippocampal volume[J]. Neurobiol Aging, 2012, 33(6):1124-1131.
[25]	Wagner A, Shannon B, Kahn I, et al. Parietal lobe contributions to episodic memory retrieval[J]. Trends Cogn Sci, 2005, 9(9):445-453. doi: 10.1016/j.tics.2005.07.001

组别	n	电针前	电针后
对照组	8	73.54±9.59	70.37±8.98^a
模型组	8	71.55±15.74	50.71±13.08
电针组	8	73.28±11.80	65.59±6.03^a
F值		0.058	6.191
P值		0.943	0.010

Effects of Electroacupuncture on Brain Function of APP/PS1 Mice: A Functional Magnetic Resonance Imaging Study

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 5

References 25

Related Articles 15

Metrics

Comments

Recommended 0

[1]	CHEN Yiting, WANG Qian, CUI Shenhong, LI Yingcai, ZHANG Siyu, WEI Yanxu, REN Hui, LENG Jun, CHEN Bin. Effect of bilateral sequential repetitive transcranial magnetic stimulation on motor function of upper limbs in stroke patients [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(8): 926-932.
[2]	CHENG Siman, XIN Rong, ZHAO Yan, LIU Qingyu, XIE Jiale, LIU Peng, WANG Pu. Functional magnetic resonance imaging study about repetitive transcranial magnetic stimulation for dysfunction after stroke: a scoping review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(2): 193-204.
[3]	ZHANG Xiaoyu,YANG Fan,WEN Jianzhong,YU Weiyong. Application of resting-state functional magnetic resonance imaging in acute mild traumatic brain injury [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(9): 1084-1088.
[4]	ZHANG Li,WU Shanhong,ZHAO Lele,WANG Yan. Role of Netrin-1 and Slit2 in regulating the imbalance of Rho GTPases after Jiaji electroacupuncture combined with nerve mobilization for sciatic nerve injury in rabbits [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(8): 914-926.
[5]	MIAO Pei,ZHANG Tong,MI Haixia,ZHANG Weidong. Learning and memory ability and its mechanism in rats with focal cerebral ischemia induced by two filament-occluded methods [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(7): 789-796.
[6]	WANG Chen,LENG Wenwu,WANG Zhipeng,CHEN Hanzhe,ZHANG Ji,XU Mingchao,ZHONG Xiaoke,JIANG Changhao. Effect of twelve-week aerobic exercise on inhibitory control abilities in overweight children [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(6): 684-689.
[7]	TIAN Jing,LIU Jue,HE Zhijie,FAN Chenyu,LI Haozheng,YANG Qing,WU Yi,YU Kewei. Brain network functional connectivity as unilateral or bilateral upper limb training for patients with upper limb motor dysfunction after stroke: study with functional near-infrared spectroscopy [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(5): 497-501.
[8]	XUAN Wenru,SHEN Yuqing,ZHOU Miao,FENG Shiwen. Bilingual training for cognition of older adults: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(5): 578-584.
[9]	CAI Guiyan,CHEN Ruilin,XU Shurui,TAO Jing,LIU Jiao. Characteristics of amplitude of low frequency fluctuation in patients with knee osteoarthritis and low back pain [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(5): 602-608.
[10]	LI Tong,FANG Zhipeng,SHAO Yuping,WANG Ping. Effect of aerobic exercise on learning and memory, and synaptic plasticity of hippocampal neurons for sleep-deprived rats [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(11): 1270-1277.
[11]	DING Yanyi,ZHANG Shenghang,LIU Yulu,YU Yan,YANG Minguang,LIANG Shengxiang,LIU Weilin,TAO Jing. Effect of electroacupuncture on regional homogeneity of brain function in rats with vascular cognitive impairment [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(1): 55-61.
[12]	LIN Ai-jin,WANG Jie-qiong,AO Li-juan,CHEN Mo-xian. Long-term Behavioral Disorder after Hypoxic Ischemic Brain Damage in Newborn Mice [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(8): 908-912.
[13]	Xiao-qian YING,Yi GAO,Li-min LIAO. Small-world Network Features of Brain Functional Network as Strong Void Perception for Healthy Female [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(5): 510-515.
[14]	Shao-hong YU,Hao-jie ZHANG,Tong ZHANG. Advance in Magnetic Resonance Imaging Research of Rehabilitation Therapy on Cerebral Network Remodeling of Motor Deficits after Stroke (review) [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(5): 516-521.
[15]	Xiao-qian YING,Li-min LIAO. Changes of Brain Functional Connections in Patients with Overactive Bladder [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(4): 466-471.