脊髓损伤神经病理性疼痛的脑电信号特征

doi:10.3969/j.issn.1006-9771.2025.07.010

Abstract

Abstract:

Objective To investigate the electroencephalography (EEG) signal characteristics in patients with neuropathic pain (NP) associated with spinal cord injury (SCI).

Methods A total of 90 patients with SCI from January, 2018 to November, 2023 were selected from the EEG database of the Department of Rehabilitation Medicine, Xijing Hospital, and divided into NP group (n = 46) and non-NP group (n = 44) according to their symptoms. The resting-state EEG power and reactivity to eye-opening were compared between two groups.

Results Compared with non-NP group, EEG power increased in frontal lobe in α and β1 bands, central lobe in δ, θ, α1 and β1 bands, parietal lobe in α and β1 bands, temporal lobe in α and β1 bands, left occipital lobe in α2 band, and occipital lobe in α1 and β1 bands (|Z| > 1.998, P < 0.05) in NP group during eye-opening; during eye-closing, EEG power increased in prefrontal lobe in α1 and β1 bands, right frontal lobe in θ band, frontal lobe in α and β1 bands, left frontal lobe in β2 band, central lobe in δ, α1 and β1 bands, parietal lobe in α1 and β1 bands, left parietal lobe in α2 and β2 bands, right temporal lobe in θ band, temporal lobe in α and β bands, occipital lobe in α1 and β1 bands, and left occipital lobe in β2 band (|Z| > 1.970, P < 0.05); while the reactivity to eye-opening decreased in right prefrontal lobe in β1 band, frontal lobe in θ, α and β bands, right central lobe in β1 band, parietal lobe in α1 and β1 bands, right parietal lobe in β2 band, right temporal lobe in δ and θ band, temporal lobe in α1 and β bands, left occipital lobe in α1 band, and occipital lobe in β1 (|Z| > 1.967, P < 0.05).

Conclusion Resting-state EEG power characteristically elevates in NP patients after SCI, and the reactivity to eye-opening reduces.

Key words: spinal cord injury, neuropathic pain, resting-state electroencephalography

CLC Number:

R651.2

LI Qiaozhen, FENG Feng, DU Xia, SHAO Wen, GAO Mi, HUI Linna, YUAN Hua, SUN Xiaolong. Characteristics of electroencephalography in neuropathic pain after spinal cord injury[J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(7): 830-837.

Figures/Tables 7

Table 1

Figure 1

Table 2

Figure 2

Table 3

Electrodes and frequency bands showing differences in power of rsEEG with eyes closed between two groups 单位：mV2"

部位	频段	组别	M (Q_u, Q_L)	Z值	P值	部位	频段	组别	M (Q_u, Q_L)	Z值	P值
FP1	α1	NP组	5.4 (2.5, 9.0)	-2.374	0.018	P3	α2	NP组	4.8 (2.5, 8.7)	-2.019	0.044
	α1	非NP组	3.2 (1.4, 5.4)	-2.374	0.018		α2	非NP组	3.2 (1.7, 5.9)	-2.019	0.044
	β1	NP组	1.3 (0.7, 1.9)	-2.086	0.037		β1	NP组	1.1 (0.7, 1.7)	-3.305	< 0.001
	β1	非NP组	0.8 (0.6, 1.3)	-2.086	0.037		β1	非NP组	0.6 (0.4, 1.0)	-3.305	< 0.001
FP2	α1	NP组	5.3 (1.8, 8.7)	-2.443	0.015		β2	NP组	0.7 (0.3, 0.9)	-2.277	0.023
	α1	非NP组	2.2 (1.3, 4.3)	-2.443	0.015		β2	非NP组	0.4 (0.3, 0.6)	-2.277	0.023
	β1	NP组	1.0 (0.7, 1.7)	-2.444	0.015	P4	α1	NP组	4.0 (1.6, 11.2)	-2.693	0.007
	β1	非NP组	0.8 (0.5, 1.1)	-2.444	0.015		α1	非NP组	1.8 (1.1, 4.6)	-2.693	0.007
F3	α1	NP组	5.1 (2.7, 7.8)	-3.088	0.002		β1	NP组	1.2 (0.6, 1.6)	-3.105	0.002
	α1	非NP组	2.3 (1.2, 4.7)	-3.088	0.002		β1	非NP组	0.8 (0.4, 0.9)	-3.105	0.002
	α2	NP组	3.7 (2.3, 7.7)	-2.878	0.004	T3	α1	NP组	1.3 (0.6, 2.2)	-2.401	0.016
	α2	非NP组	2.1 (1.3, 3.6)	-2.878	0.004		α1	非NP组	0.7 (0.3, 1.9)	-2.401	0.016
	β1	NP组	1.0 (0.6, 1.8)	-3.448	< 0.001		α2	NP组	1.4 (0.9, 2.7)	-2.676	0.007
	β1	非NP组	0.7 (0.4, 1.0)	-3.448	< 0.001		α2	非NP组	0.9 (0.6, 1.7)	-2.676	0.007
	β2	NP组	0.7 (0.4, 1.3)	-2.351	0.019		β1	NP组	0.6 (0.3, 1.1)	-2.507	0.012
	β2	非NP组	0.5 (0.4, 0.7)	-2.351	0.019		β1	非NP组	0.4 (0.2, 0.7)	-2.507	0.012
F4	θ	NP组	4.1 (3.0, 6.0)	-2.184	0.029	T5	α1	NP组	4.2 (1.5, 10.8)	-2.362	0.018
	θ	非NP组	3.0 (1.8, 5.1)	-2.184	0.029		α1	非NP组	2.3 (0.7, 5.0)	-2.362	0.018
	α1	NP组	4.6 (2.3, 8.6)	-3.270	0.001		β1	NP组	0.7 (0.6, 1.3)	-3.133	0.002
	α1	非NP组	2.1 (1.3, 4.3)	-3.270	0.001		β1	非NP组	0.5 (0.4, 0.9)	-3.133	0.002
	α2	NP组	4.6 (1.9, 7.4)	-2.370	0.018		β2	NP组	0.5 (0.4, 0.9)	-2.271	0.023
	α2	非NP组	2.5 (1.1, 4.0)	-2.370	0.018		β2	非NP组	0.4 (0.3, 0.6)	-2.271	0.023
	β1	NP组	1.0 (0.7, 1.7)	-2.932	0.003	T6	θ	NP组	1.9 (1.2, 2.7)	-2.219	0.026
	β1	非NP组	0.7 (0.4, 1.0)	-2.932	0.003		θ	非NP组	1.4 (0.9, 2.0)	-2.219	0.026
F7	α1	NP组	1.2 (0.8, 2.5)	-2.579	0.010		α1	NP组	5.1 (1.4, 9.5)	-2.786	0.005
	α1	非NP组	0.9 (0.4, 1.8)	-2.579	0.010		α1	非NP组	2.6 (0.7, 5.2)	-2.786	0.005
	α2	NP组	1.4 (0.9, 2.0)	-2.417	0.016		α2	NP组	2.8 (1.8, 7.7)	-1.970	0.049
	α2	非NP组	0.9 (0.6, 1.5)	-2.417	0.016		α2	非NP组	2.1 (1.1, 4.7)	-1.970	0.049
F8	α1	NP组	1.4 (0.7, 2.9)	-2.525	0.012		β1	NP组	0.7 (0.5, 1.5)	-3.266	0.001
F8	α1	非NP组	0.8 (0.4, 1.3)	-2.525	0.012		β1	非NP组	0.5 (0.4, 0.8)	-3.266	0.001
C3	δ	NP组	3.0 (2.3, 3.6)	-2.117	0.034		β2	NP组	0.6 (0.4, 0.9)	-2.335	0.020
	δ	非NP组	2.6 (2.0, 3.3)	-2.117	0.034		β2	非NP组	0.4 (0.3, 0.6)	-2.335	0.020
	α1	NP组	4.0 (2.0, 6.7)	-2.317	0.020	O1	α1	NP组	10.4 (3.7, 30.7)	-2.337	0.019
	α1	非NP组	2.4 (1.1, 4.4)	-2.317	0.020		α1	非NP组	5.4 (1.8, 8.7)	-2.337	0.019
	β1	NP组	1.0 (0.5, 1.4)	-2.397	0.017		β1	NP组	1.6 (1.2, 2.7)	-3.331	< 0.001
	β1	非NP组	0.6 (0.4, 1.0)	-2.397	0.017		β1	非NP组	1.0 (0.7, 1.4)	-3.331	< 0.001
C4	δ	NP组	3.1 (2.2, 4.0)	-2.435	0.015		β2	NP组	1.0 (0.6, 1.8)	-2.187	0.029
	δ	非NP组	2.5 (1.7, 3.3)	-2.435	0.015		β2	非NP组	0.7 (0.5, 1.1)	-2.187	0.029
	α1	NP组	3.2 (1.7, 8.1)	-2.336	0.018	O2	α1	NP组	5.9 (3.2, 29.1)	-2.038	0.042
	α1	非NP组	2.1 (0.7, 3.6)	-2.336	0.018		α1	非NP组	4.6 (1.9, 6.9)	-2.038	0.042
	β1	NP组	0.9 (0.6, 1.4)	-2.254	0.024		β2	NP组	1.5 (1.0, 2.2)	-2.744	0.006
	β1	非NP组	0.7 (0.4, 0.9)	-2.254	0.024		β2	非NP组	1.0 (0.6, 1.5)	-2.744	0.006
P3	α1	NP组	4.5 (2.3, 8.7)	-2.887	0.004
P3	α1	非NP组	2.2 (0.8, 5.3)	-2.887	0.004

Table 3

Figure 3

Table 4

Electrodes and frequency bands showing differences in reaction between two groups 单位：mV2"

部位	频段	组别	M (Q_u, Q_L)	Z值	P值	部位	频段	组别	M (Q_u, Q_L)	Z值	P值
FP2	β1	NP组	-0.1 (-0.5, 0.3)	-2.208	0.027		β1	NP组	-0.3 (-0.7, -0.1)	-2.334	0.020
FP2	β1	非NP组	0.0 (-0.2, 0.1)	-2.208	0.027		β1	非NP组	-0.2 (-0.3, -0.1)	-2.334	0.020
F3	θ	NP组	-1.0 (-2.1, 0.0)	-1.967	0.049		β2	NP组	-0.1 (-0.3, 0.0)	-2.384	0.017
	θ	非NP组	-0.5 (-1.2, 0.2)	-1.967	0.049		β2	非NP组	0.0 (-0.2, 0.0)	-2.384	0.017
	α1	NP组	-3.5 (-6.1, -1.4)	-2.608	0.009	P4	α1	NP组	-2.8 (-9.4, -0.8)	-2.092	0.036
	α1	非NP组	-1.2 (-4.0, -0.5)	-2.608	0.009		α1	非NP组	-1.1 (-3.7, -0.4)	-2.092	0.036
	α2	NP组	-1.8 (-6.1, -0.9)	-2.152	0.031		β1	NP组	-0.3 (-0.7, -0.1)	-2.728	0.006
	α2	非NP组	-1.2 (-2.6, -0.2)	-2.152	0.031		β1	非NP组	-0.2 (-0.3, 0.0)	-2.728	0.006
	β1	NP组	-0.2 (-0.7, 0.0)	-2.593	0.010	T3	β1	NP组	-0.1 (-0.3, 0.0)	-3.484	< 0.001
	β1	非NP组	-0.1 (-0.2, 0.0)	-2.593	0.010		β1	非NP组	0.0 (-0.1, 0.1)	-3.484	< 0.001
	β2	NP组	-0.1 (-0.3, 0.0)	-3.545	< 0.001		β2	NP组	0.0 (-0.1, 0.0)	-2.515	0.012
	β2	非NP组	0.0 (-0.1, 0.1)	-3.545	< 0.001		β2	非NP组	0.0 (0.0, 0.1)	-2.515	0.012
F4	θ	NP组	-0.9 (-1.9, -0.2)	-1.975	0.048	T5	α1	NP组	-2.8 (-9.8, -1.0)	-2.160	0.031
	θ	非NP组	-0.2 (-1.2, 0.1)	-1.975	0.048		α1	非NP组	-1.7 (-4.4, -0.3)	-2.160	0.031
	α1	NP组	-3.6 (-6.7, -1.1)	-2.838	0.005		β1	NP组	-0.3 (-0.6, -0.1)	-2.780	0.005
	α1	非NP组	-1.0 (-3.5, -0.5)	-2.838	0.005		β1	非NP组	-0.1 (-0.2, 0.1)	-2.780	0.005
	α2	NP组	-2.3 (-6.3, -0.8)	-2.092	0.036		β2	NP组	-0.1 (-0.2, 0.0)	-2.459	0.014
	α2	非NP组	-1.4 (-2.8, -0.3)	-2.092	0.036		β2	非NP组	0.0 (-0.1, 0.0)	-2.459	0.014
	β1	NP组	-0.2 (-0.5, 0.0)	-2.396	0.017	T6	δ	NP组	-0.2 (-0.4, 0.1)	-2.151	0.031
	β1	非NP组	-0.1 (-0.3, 0.0)	-2.396	0.017		δ	非NP组	0.1 (-0.3, 0.6)	-2.151	0.031
	β2	NP组	-0.1 (-0.3, 0.0)	-1.996	0.046		θ	NP组	-0.6 (-1.4, -0.1)	-2.706	0.007
	β2	非NP组	0.0 (-0.2, 0.1)	-1.996	0.046		θ	非NP组	-0.2 (-0.6, 0.0)	-2.706	0.007
F7	α1	NP组	-0.7 (-1.8, -0.3)	-2.427	0.015		α1	NP组	-4.5 (-6.8, -0.9)	-2.549	0.011
	α1	非NP组	-0.3 (-1.0, -0.1)	-2.427	0.015		α1	非NP组	-1.7 (-4.1, -0.3)	-2.549	0.011
	α2	NP组	-0.7 (-1.3, -0.1)	-2.036	0.042		β1	NP组	-0.3 (-0.6, -0.1)	-2.524	0.012
	α2	非NP组	-0.3 (-0.7, 0.0)	-2.036	0.042		β1	非NP组	-0.1 (-0.3, 0.0)	-2.524	0.012
	β1	NP组	-0.1 (-0.3, 0.0)	-3.333	< 0.001		β2	NP组	-0.1 (-0.2, 0.0)	-2.137	0.033
	β1	非NP组	0.0 (0.0, 0.1)	-3.333	< 0.001		β2	非NP组	-0.1 (-0.1, 0.0)	-2.137	0.033
	β2	NP组	0.0 (-0.1, 0.1)	-2.142	0.032	O1	α1	NP组	-6.7 (-23.7, -2.7)	-2.220	0.026
	β2	非NP组	0.1 (0.0, 0.2)	-2.142	0.032		α1	非NP组	-3.9 (-8.2, -0.9)	-2.220	0.026
F8	α1	NP组	-1.1 (-2.0, -0.2)	-2.682	0.007		β1	NP组	-0.8 (-1.3, -0.3)	-2.518	0.012
F8	α1	非NP组	-0.3 (-0.9, 0.0)	-2.682	0.007		β1	非NP组	-0.4 (-0.6, -0.1)	-2.518	0.012
C4	β1	NP组	-0.2 (-0.5, -0.1)	-3.044	0.002	O2	β1	NP组	-0.8 (-1.2, -0.3)	-2.463	0.014
C4	β1	非NP组	-0.1 (-0.2, 0.0)	-3.044	0.002	O2	β1	非NP组	-0.3 (-0.8, -0.1)	-2.463	0.014
P3	α1	NP组	-3.1 (-6.7, -1.2)	-2.402	0.016
P3	α1	非NP组	-1.2 (-3.8, -0.3)	-2.402	0.016

Table 4

References 22

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组别	n	年龄/岁	性别(男/女)/n	脊髓损伤节段(颈/胸/腰/骶)/n	损伤分级(A/B/C/D)/n
NP组	46	41.0 (30.0, 49.0)	38/8	20/18/8/0	24/4/12/6
非NP组	44	43.0 (29.0, 50.8)	35/9	25/13/5/1	22/8/4/10
χ²/Z值		-0.121	0.138	3.011	6.379
P值		0.904	0.711	0.390	0.095

Characteristics of electroencephalography in neuropathic pain after spinal cord injury

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部位	频段	组别	M (Q_u, Q_L)	Z值	P值	部位	频段	组别	M (Q_u, Q_L)	Z值	P值
F3	α1	NP组	1.2 (0.8, 1.8)	-2.872	0.004	P3	α2	NP组	1.3 (1.0, 1.8)	-2.146	0.032
	α1	非NP组	0.8 (0.5, 1.1)	-2.872	0.004		α2	非NP组	1.1 (0.7, 1.5)	-2.146	0.032
	α2	NP组	1.4 (1.0, 1.9)	-2.862	0.004		β1	NP组	0.7 (0.4, 0.9)	-2.266	0.023
	α2	非NP组	1.0 (0.7, 1.5)	-2.862	0.004		β1	非NP组	0.5 (0.3, 0.8)	-2.266	0.023
	β1	NP组	0.7 (0.5, 1.3)	-2.496	0.013	P4	α1	NP组	1.1 (0.6, 1.6)	-2.718	0.007
	β1	非NP组	0.6 (0.4, 0.8)	-2.496	0.013		α1	非NP组	0.6 (0.4, 1.0)	-2.718	0.007
F4	α1	NP组	1.1 (0.7, 1.7)	-2.270	0.023		β1	NP组	0.7 (0.5, 1.0)	-2.137	0.033
F4	α1	非NP组	0.7 (0.5, 1.3)	-2.270	0.023		β1	非NP组	0.5 (0.4, 0.7)	-2.137	0.033
C3	δ	NP组	3.3 (2.3, 4.4)	-2.023	0.043	T3	α1	NP组	0.5 (0.3, 0.6)	-2.418	0.016
	δ	非NP组	2.7 (2.0, 3.7)	-2.023	0.043		α1	非NP组	0.4 (0.2, 0.5)	-2.418	0.016
	α1	NP组	1.2 (0.5, 1.5)	-1.970	0.049		α2	NP组	0.8 (0.5, 1.1)	-2.030	0.042
	α1	非NP组	0.7 (0.4, 1.1)	-1.970	0.049		α2	非NP组	0.7 (0.4, 0.8)	-2.030	0.042
	β1	NP组	0.7 (0.4, 1.0)	-1.998	0.046	T6	α1	NP组	0.6 (0.4, 1.1)	-2.615	0.009
	β1	非NP组	0.5 (0.3, 0.7)	-1.998	0.046		α1	非NP组	0.4 (0.3, 0.6)	-2.615	0.009
C4	δ	NP组	3.0 (2.2, 4.4)	-2.245	0.025		β1	NP组	0.6 (0.3, 0.9)	-2.442	0.015
	δ	非NP组	2.4 (1.4, 3.6)	-2.245	0.025		β1	非NP组	0.4 (0.3, 0.6)	-2.442	0.015
	θ	NP组	2.5 (1.8, 3.4)	-2.213	0.027	O1	α2	NP组	2.0 (1.5, 3.2)	-2.161	0.031
	θ	非NP组	1.8 (1.1, 3.4)	-2.213	0.027		α2	非NP组	1.4 (1.0, 2.6)	-2.161	0.031
	α1	NP组	0.9 (0.6, 1.5)	-2.160	0.031		β1	NP组	0.9 (0.5, 1.4)	-2.035	0.042
	α1	非NP组	0.6 (0.3, 1.0)	-2.160	0.031		β1	非NP组	0.7 (0.4, 0.9)	-2.035	0.042
P3	α1	NP组	1.1 (0.6, 1.7)	-2.529	0.011	O2	α1	NP组	1.1 (0.8, 2.1)	-2.215	0.027
P3	α1	非NP组	0.7 (0.4, 1.2)	-2.529	0.011	O2	α1	非NP组	0.8 (0.6, 1.6)	-2.215	0.027

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