帕金森病患者不同程度抑郁在汉密尔顿抑郁量表的结构差异

doi:10.3969/j.issn.1006-9771.2021.07.015

Abstract

Abstract:

Objective To explore the structural differences and the trend in series scores of Hamilton Depression Scale (HAMD) in patients with Parkinson's disease (PD).

Methods From June, 2017 to March, 2018, 168 PD patients from Beijing Tiantan Hospital were reviewed. Their genders, ages, courses of disease, Hamilton Depression Scale (HAMD) scores, unified Parkinson's disease rating scale III (UPDRS III) scores,Hoehn-Yahr stage and Mini-Mental State Examination (MMSE) scores, the most improvement ratios by PD drug and other clinical data were collected. The patients were divided into non-depression group (n = 61), mild depression group (n = 68) and moderate depression group (n= 39) according to the HAMD scores. The series scores of HAMD among the groups were compared.

Results The factor scores all increased with depression exacerbating (F > 10.546, P < 0.001), except day and night change in the mild depression group, while the proportion of anxiety/somatization score decreased, and the proportion of cognitive disorder and retardant scores increased.

Conclusion The depression structure changes in PD patients with depression exacerbating, which means decrease of anxiety/somatization and increase of cognitive disorder and retardant.

Key words: Parkinson's disease, depression, Hamilton Depression Scale, structural differences

CLC Number:

R742.5

MA Hui-zi,FANG Jin-ping,FENG Tao,JIANG Ying. Structural Differences of Depression for Patients with Parkinson's Disease Using Hamilton Depression Scale[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(7): 829-833.

Figures/Tables 3

References 33

[1]	RAZA C, ANJUM R, SHAKEEL N U A. Parkinson's disease: mechanisms, translational models and management strategies[J]. Life Sci, 2019, 226(1):77-90. doi: 10.1016/j.lfs.2019.03.057
[2]	RAY S, AGARWAL P. Depression and anxiety in Parkinson disease[J]. Clin Geriatr Med, 2020, 36(1):93-104. doi: 10.1016/j.cger.2019.09.012
[3]	JANKOVIC J, TAN E K. Parkinson's disease: etiopathogenesis and treatment[J]. J Neurol Neurosurg Psychiatry, 2020, 91(8):795-808. doi: 10.1136/jnnp-2019-322338
[4]	LIN H, CAI X, ZHANG D, et al. Functional connectivity markers of depression in advanced Parkinson's disease[J]. Neuroimage Clin, 2020, 25:102130. doi: 10.1016/j.nicl.2019.102130
[5]	陈菊萍, 韩漾, 缪虹, 等. 帕金森病患者睡眠质量、情绪对其照料者的影响[J]. 中华医学杂志, 2020, 100(43):3414-3418.
	CHEN J P, HAN Y, MIAO H, et al. Effects of sleep quality and mood of patients with Parkinson's disease on their caregivers[J]. Natl Med J Chin, 2020, 100(43):3414-3418.
[6]	孙政, 杜小静, 马建军, 等. 抑郁对不同运动亚型帕金森病患者生活质量的影响[J]. 中华老年心脑血管病杂志, 2019, 21(2):129-132.
	SUN Z, DU X J, MA J J, et al. Effect of depression on quality of life in patients with different motor subtypes of PD[J]. Chin J Geriatr Heart Brain Ves Dis, 2019, 21(2):129-132.
[7]	蒋岩岩, 陈海波, 龙云飞, 等. 抑郁症状对中老年帕金森病患者生活质量影响的随访研究[J]. 中华老年医学杂志, 2019, 38(7):755-759.
	JIANG Y Y, CHEN H B, LONG Y F, et al. Effect of depressive symptoms on quality of life in middle-aged and elderly patients with Parkinson's disease: a 4-year follow-up study[J]. Chin J Geriatr, 2019, 38(7):755-759.
[8]	米国新, 冯涛, 刘卓. 帕金森病患者日常生活活动能力的调查[J]. 中国康复理论与实践, 2012, 18(3):265-266.
	MI G X, FENG T, LIU Z. Activity of daily living of patients with Parkinson's disease[J]. Chin J Rehabil Theory Pract, 2012, 18(3):265-266.
[9]	ARMSTRONG M J, OKUN M S. Diagnosis and treatment of Parkinson disease: a review[J]. JAMA, 2020, 323(6):548-560. doi: 10.1001/jama.2019.22360
[10]	金丽莹, 苏闻, 金莹, 等. 帕金森病抑郁及其对生活质量的影响[J]. 中华神经科杂志, 2018, 51(7):510-514.
	JIN L Y, SU W, JIN Y, et al. Depression and its effects on quality of life in patients of Parkinson's disease[J]. Chin J Neurol, 2018, 51(7):510-514.
[11]	陈生弟. 帕金森病伴发抑郁症状的诊断及治疗[J]. 中华老年医学杂志, 2018, 37(4):372-376.
	CHEN S D. Diagnosis and therapy of depressive symptoms in Parkinson's disease[J]. Chin J Geriatr, 2018, 37(4):372-376.
[12]	SCHRAG A, TADDEI R N. Depression and anxiety in Parkinson's disease[J]. Int Rev Neurobiol, 2017, 133:623-655.
[13]	LIU Y, ZHU X Y, ZHANG X J, et al. Clinical features of Parkinson's disease with and without rapid eye movement sleep behavior disorder[J]. Transl Neurodegener, 2017, 6:35. doi: 10.1186/s40035-017-0105-5
[14]	POSTUMA R B, BERG D, STERN M, et al. MDS clinical diagnostic criteria for Parkinson's disease[J]. Mov Disord, 2015, 30(12):1591-1601. doi: 10.1002/mds.26424
[15]	MENDONÇA I P, DUARTE-SILVA E, CHAVES-FILHO A J M, et al. Neurobiological findings underlying depressive behavior in Parkinson's disease: a review[J]. Int Immunopharmacol, 2020, 83:106434. doi: 10.1016/j.intimp.2020.106434
[16]	程畅, 施梅. 抗抑郁药物治疗帕金森病伴抑郁的研究进展[J]. 神经损伤与功能重建, 2020, 15(8):466-468.
	CHENG C, SHI M. The progress of the researches on the antidepressant treatment of Parkinson's disease with depression[J]. Neural Injury Func Reconstruc, 2020, 15(8):466-468.
[17]	RYAN M, EATMON C V, SLEVIN J T. Drug treatment strategies for depression in Parkinson disease[J]. Expert Opin Pharmacother, 2019, 20(11):1351-1363. doi: 10.1080/14656566.2019.1612877
[18]	ASSOGNA F, PELLICANO C, SAVINI C, et al. Drug choices and advancements for managing depression in Parkinson's disease[J]. Curr Neuropharmacol, 2020, 18(4):277-287. doi: 10.2174/1570159X17666191016094857
[19]	袁德智, 胡洁, 赵秋叶, 等. 帕金森病进展速度与抑郁、睡眠障碍的相关性分析[J]. 中国医科大学学报, 2020, 49(4):326-330.
	YUAN D Z, HU J, ZHAO Q Y, et al. Correlation between progression of Parkinson disease and depression and sleep disorders[J]. J Chin Med Univ, 2020, 49(4):326-330.
[20]	王雪梅, 冯涛, 陈慧敏, 等. 帕金森抑郁与运动障碍相关性分析[J]. 中国医药导报, 2017, 14(35):4-7, 24.
	WANG X M, FENG T, CHEN H M, et al. Analysis of correlation between depression and motor dysfunction in Parkinson's diseases[J]. Chin Med Herald, 2017, 14(35):4-7, 24.
[21]	NICOLETTI A, VASTA R, MOSTILE G, et al. Gender effect on non-motor symptoms in Parkinson's disease: are men more at risk?[J]. Parkinsonism Relat Disord, 2017, 35:69-74. doi: 10.1016/j.parkreldis.2016.12.008
[22]	DAUWAN M, BEGEMANN M J H, SLOT M I E, et al. Physical exercise improves quality of life, depressive symptoms, and cognition across chronic brain disorders: a transdiagnostic systematic review and meta-analysis of randomized controlled trials[J]. J Neurol, 2021, 268(4):1222-1246. doi: 10.1007/s00415-019-09493-9
[23]	张婷婷, 李涛, 梁战华. 帕金森病患者抑郁状况及影响因素分析[J]. 中华医学杂志, 2018, 98(31):2515-2517.
	ZHANG T T, LI T, LIANG Z H. Analysis of depression status and influence factors in Parkinson's disease[J]. Nat Med J Chin, 2018, 98(31):2515-2517.
[24]	洪紫静, 周玮, 胡蓉蓉, 等. 轻度认知功能障碍与老年抑郁关系的研究进展[J]. 中国康复理论与实践, 2018, 24(9):1052-1054.
	HONG Z J, ZHOU W, HU R R, et al. Advance in researches of relationship between mild cognitive impairment and late life depression (review)[J]. Chin J Rehabil Theory Pract, 2018, 24(9):1052-1054.
[25]	DALLÉ E, MABANDLA M V. Early life stress, depression and Parkinson's disease: a new approach[J]. Mol Brain, 2018, 11(1):18. doi: 10.1186/s13041-018-0356-9
[26]	武冬冬, 苏闻, 李淑华, 等. 帕金森病患者睡眠障碍情况的问卷调查[J]. 中华全科医师杂志, 2018, 17(8):591-595.
	WU D D, SU W, LI S H, et al. Survey on sleep disorders in patients with Parkinson disease[J]. Chin J Gen Prac, 2018, 17(8):591-595.
[27]	王雪梅, 冯涛, 顾朱勤, 等. 基于临床异质性的帕金森病患者抑郁分析[J]. 中国康复理论与实践, 2015, 21(2):220-223.
	WANG X M, FENG T, GU Z Q, et al. Condition of depression based on the clinical heterogeneity of idiopathic Parkinson's disease[J]. Chin J Rehabil Theory Pract, 2015, 21(2):220-223.
[28]	王珊珊, 李晓红. 帕金森病患者色觉功能与焦虑和抑郁的相关性[J]. 中国康复理论与实践, 2020, 26(3):359-362.
	WANG S S, LI X H. Correlation of color vision to anxiety and depression in patients with Parkinson's disease[J]. Chin J Rehabil Theory Pract, 2020, 26(3):359-362.
[29]	BAIANO C, BARONE P, TROJANO L, et al. Prevalence and clinical aspects of mild cognitive impairment in Parkinson's disease: a meta-analysis[J]. Mov Disord, 2020, 35(1):45-54. doi: 10.1002/mds.v35.1
[30]	崔立玲, 于洋, 王玥, 等. Valpar训练系统对帕金森病患者的疗效[J]. 中国康复理论与实践, 2018, 24(7):767-772.
	CUI L L, YU Y, WANG Y, et al. Effects of Valpar component work sample on Parkinson's disease[J]. Chin J Rehabil Theory Pract, 2018, 24(7):767-772.
[31]	张倩, 张宁, 刘金凤, 等. 正念干预治疗脑卒中患者抑郁效果的Meta分析[J]. 中国康复理论与实践, 2018, 24(12):1479-1484.
	ZHANG Q, ZHANG N, LIU J F, et al. Effect of mindfulness-based therapy on depression for stroke patients: a meta-analysis[J]. Chin J Rehabil Theory Pract, 2018, 24(12):1479-1484.
[32]	杨剑, 梁艳, 邱卓英, 等. 身心锻炼干预抑郁症有效性的Meta分析[J]. 中国康复理论与实践, 2019, 25(11):1260-1271.
	YANG J, LIANG Y, QIU Z Y, et al. Effects of mind-body exercise on depression: a meta-analysis[J]. Chin J Rehabil Theory Pract, 2019, 25(11):1260-1271.
[33]	陈思, 刘杰, 李顺, 等. 虚拟现实技术对帕金森病患者平衡功能的影响[J]. 中国康复理论与实践, 2017, 23(9):1091-1095.
	CHEN S, LIU J, LI S, et al. Effects of virtual reality rehabilitation on balance for patients with Parkinson's disease[J]. Chin J Rehabil Theory Pract, 2017, 23(9):1091-1095.

项目	无抑郁组(n = 61)	轻度抑郁组(n = 68)	中度抑郁组(n = 39)	F/χ²值	P值
性别(男/女, n)	34/27	33/35	28/11	0.064	0.969
年龄(岁)	63.61±9.99	61.74±11.50	60.03±11.97	1.276	0.282
病程(年)	4.91±3.47	6.53±4.62^a	7.74±4.44^a	5.732	0.004
H-Y分期	2.39±0.69	2.42±0.84	2.72±0.92	2.265	0.108
UPDRSⅢ评分	29.68±30.96	32.44±13.61	36.84±14.86	1.287	0.279
抗帕金森病药物最大改善率(%)	28.63±15.78	37.60±20.18^a	37.58±18.11^a	4.707	0.003
MMSE评分	22.50±7.77	24.41±6.51	21.67±7.29	2.123	0.230
起病形式(n)				0.048	1.000
震颤	26	28	13
运动迟缓	29	24	23
其他	6	16	3

项目	无抑郁组(n= 61)	轻度抑郁组(n= 68)	中度抑郁组(n= 39)	F值	P值
焦虑/躯体化	2.05±1.347	4.40±1.405^a	6.10±1.971^a,b	88.010	< 0.001
体质量减轻	0.18±0.466	0.53±0.782^a	0.85±0.904^a,b	10.546	< 0.001
认知障碍	0.13±0.340	0.69±0.950^a	2.56±2.437^a,b	41.366	< 0.001
日夜变化	0.05±0.284	0.13±0.383	0.69±0.922^a,b	19.282	< 0.001
阻滞	0.44±0.742	2.88±1.511^a	4.74±1.499^a,b	140.850	< 0.001
睡眠障碍	0.75±1.011	3.01±2.033^a	4.51±1.571^a,b	69.062	< 0.001
绝望感	0.85±1.138	2.90±1.426^a	4.46±1.411^a,b	92.942	< 0.001

Structural Differences of Depression for Patients with Parkinson's Disease Using Hamilton Depression Scale

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 3

References 33

Related Articles 15

Metrics

Comments

Recommended 0

[1]	ZHANG Liyin. Depression in Parkinson's disease and its association with cognition, balance and quality of life [J]. Chinese Journal of Rehabilitation Theory and Practice, 2026, 32(2): 174-180.
[2]	DU Lilu, YAO Renkui, ZHAO Yanyu, LI Mengxuan, ZOU Min, ZHANG Gongfa. Impact of meaning in life and living arrangements on association between activities of daily living and depression in older adults [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(8): 987-992.
[3]	SHAN Lei, LIU Ying, ZHANG Xin, CHI Qianqian, ZHU Xiaomin. Effect of accelerated intermittent theta burst stimulation on post-stroke depression [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(7): 822-829.
[4]	YANG Yicheng, WANG Dandan, SHEN Qunce, ZHANG Lei, WU Xueping. Effect of exercise on cancer patients with anxiety and depression during chemotherapy: a meta-analysis [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(2): 184-193.
[5]	XIE Haixia, HU Xinxing, ZHAI Hua, LIN Peipei, HE Jianhui, ZHANG Jia, DONG Xiaowan, CHANG Fengshui. Effect of life reconstruction training on anxiety and depression among individuals with chronic spinal cord injury and their caregivers [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(11): 1333-1341.
[6]	CHEN Yuhang, YANG Yu'ai, LU Xuanyu, WANG Yuhang, ZHANG Mengyuan, ZHANG Zihan, WANG Huiying, CHANG Jingling. Spontaneous brain activity changes in post-stroke aphasia and post-stroke depression: a meta-analysis of resting state functional magnetic resonance imaging [J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(10): 1143-1155.
[7]	SU Rufeng, ZHONG Xiaoke, GAO Xiaoyan, JIANG Changhao. Application of artificial intelligence in anxiety and depression among children and adolescents: a scoping review [J]. Chinese Journal of Rehabilitation Theory and Practice, 2024, 30(5): 513-519.
[8]	LI Fang, LIU Huizhen, MEI Liping, ZHANG Tong, ZHANG Haojie, LI Bingjie, ZHAO Jun. Related factors of post-stroke depression in patients with cerebral infarction during hospitalization in rehabilitation department [J]. Chinese Journal of Rehabilitation Theory and Practice, 2024, 30(2): 217-222.
[9]	ZHANG Minglan, ZHANG Lingling, WANG Lisha, LIU Li, GAO Run, RAO Jiang, LIU Wan, XIA Zi'an, ZHANG Chuanwen, CHENG Xinxin. Impact of autonomic nerve function on motor function in patients with post-stroke depression [J]. Chinese Journal of Rehabilitation Theory and Practice, 2024, 30(2): 223-231.
[10]	CAI Siyan, FAN Yingjie, TIAN Huifang, XIA Chunya, ZHANG Juan, SU Min. Effect of transcranial direct current stimulation based on music therapy on insomnia: a randomized controlled trial [J]. Chinese Journal of Rehabilitation Theory and Practice, 2024, 30(10): 1193-1202.
[11]	ZHANG Jingya, ZOU Min, SUN Hongwei, SUN Changlong, ZHU Juntong. Effect of psychological intervention on anxiety or depression in children and adolescents with hearing impairment: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1004-1011.
[12]	ZHANG Mengjie, DAI Yuanfu, WANG Chen, XIE Difa, JIANG Changhao. Aerobic activity reducing depression in school-age children: a multiple mediation effects analysis based on five dimensions of psychosocial functioning [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(1): 12-19.
[13]	QIN Yanqiang, DONG Hao, SUN Yingchun, CHENG Xiankuan, YAO Haijiang. Effects of different acupuncture schemes on neurotransmitters and related inflammatory factors in rats with post-stroke depression [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(1): 30-37.
[14]	CUI Jiabao, LIN Jian, LIU Yucheng, WANG Peng, ZENG Hongfa. Mental health benefits of Tai Chi for college students: a systematic review using ICF [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(1): 48-54.
[15]	XI Xiaoming,BI Hongyan. Effect of abdominal torsion movement on depression, constipation, motor symptoms and quality of life in patients with Parkinson's disease [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(2): 220-226.