脑机接口联合上肢康复机器人对脑卒中患者上肢功能的影响

doi:10.3969/j.issn.1006-9771.2025.06.011

Abstract

Abstract:

Objective To explore the effect of motor imagery brain-computer interface (BCI) combined with upper limb rehabilitation robot on upper limb function of stroke patients.

Methods From May to December, 2024, 45 stroke inpatients from Xuzhou Rehabilitation Hospital and Xuzhou Central Hospital were recruited and randomly divided into BCI group (n = 15), robot group (n = 15) and combined group (n = 15). All the groups received conventional rehabilitation therapy. On this basis, the BCI group received motor imagery based BCI training, the robot group received upper extremity rehabilitation robot training, and the combined group received BCI combined with upper extremity rehabilitation robot training. They were assessed with Fugl-Meyer Assessment-Upper Extremities (FMA-UE), Action Research Arm Test (ARAT) and modified Barthel Index (MBI) before and four weeks after treatment, while they were measured delta-alpha ratio (DAR) using the quantitative electroencephalogram.

Results The intra-group effect (F> 101.870, P< 0.001) and interaction effect (F> 7.891, P< 0.001) were significant in the scores of FMA-UE, ARAT and MBI, and DAR. Post Hoc test showed that all the indexes were better in the combined group than in BCI group and the robot group (P < 0.05), and there was no significant difference in the indexes between BCI group and the robot group (P > 0.05).

Conclusion BCI combined with upper limb rehabilitation robot can promote the recovery of upper limb function and activities of daily living of stroke patients.

Key words: stroke, upper limb, motor function, brain-computer interface, upper limb rehabilitation robots

CLC Number:

R743.3

LIU Xuan, GAO Ling, CHU Fengming, CHEN Jie, ZHANG Ming. Effect of brain-computer interface combined with upper limb rehabilitation robot on upper limb function of stroke patients[J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(6): 703-710.

Figures/Tables 6

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References 43

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组别	n	性别(男/女)/n	年龄/岁	病程/d	病变性质(缺血/出血)/n	偏瘫侧(左/右)/n
脑机接口组	15	5/10	56.13±10.83	52.80±13.17	4/11	7/8
机器人组	15	4/11	57.00±9.59	61.33±22.28	2/13	7/8
联合组	15	5/10	61.60±6.85	64.80±19.48	5/10	6/9
χ²/F值		0.211	1.516	1.635	1.780	0.180
P值		0.900	0.231	0.207	0.411	0.914

变量	组别	治疗前		治疗后
变量	组别	均值	标准差	均值	标准差
FMA-UE	脑机接口组	28.00	3.85	33.80	3.82
	机器人组	27.73	5.50	33.40	5.60
	联合组	25.87	6.55	38.93	8.56
ARAT	脑机接口组	10.20	4.46	16.07	4.17
	机器人组	11.67	5.86	15.93	5.48
	联合组	12.13	5.25	22.67	5.43
MBI	脑机接口组	54.40	10.95	60.27	10.26
	机器人组	52.53	9.53	59.80	9.14
	联合组	56.27	6.95	67.27	7.08
DAR	脑机接口组	3.22	1.17	2.51	0.99
	机器人组	3.12	0.77	2.57	0.80
	联合组	3.30	1.33	1.71	0.93

变量		平方和	自由度	均方	F值	P值
FMA-UE	组内	1504.711	1	1504.711	342.846	< 0.001
	组间	57.222	2	28.611	0.443	0.645
	组内×组间	268.956	2	134.478	30.641	< 0.001
ARAT	组内	953.878	1	953.878	336.851	< 0.001
	组间	183.267	2	91.633	1.683	0.198
	组内×组间	44.689	2	22.344	7.891	< 0.001
MBI	组内	1456.044	1	1456.044	662.316	< 0.001
	组间	523.756	2	261.878	1.599	0.214
	组内×组间	105.622	2	52.811	24.022	< 0.001
DAR	组内	20.268	1	20.268	101.870	< 0.001
	组间	2.466	2	1.233	0.657	0.523
	组内×组间	4.756	2	2.378	11.953	< 0.001

变量	组别	治疗前后平均值差	平均值差标准差	P值	95%CI
变量	组别	治疗前后平均值差	平均值差标准差	P值	下限	上限
FMA-UE	脑机接口组	-5.800	1.821	< 0.001	-7.344	-4.256
	机器人组	-5.667	1.633	< 0.001	-7.210	-4.123
	联合组	-13.067	4.511	< 0.001	-14.610	-11.523
ARAT	脑机接口组	-5.867	1.995	< 0.001	-7.107	-4.627
	机器人组	-5.200	1.373	< 0.001	-6.440	-3.960
	联合组	-8.467	3.335	< 0.001	-9.707	-7.227
MBI	脑机接口组	-5.867	1.457	< 0.001	-6.959	-4.774
	机器人组	-7.267	1.831	< 0.001	-8.359	-6.174
	联合组	-11.000	2.777	< 0.001	-12.093	-9.907
DAR	脑机接口组	0.712	0.450	< 0.001	0.383	1.041
	机器人组	0.543	0.249	0.002	0.215	0.872
	联合组	1.592	0.964	< 0.001	1.263	1.921

变量	组别	组别	均值差	P值	95%CI
变量	组别	组别	均值差	P值	下限	上限
FMA-UE	脑机接口组	机器人组	0.267	0.893	-3.722	4.256
	脑机接口组	联合组	2.133	0.287	-1.856	6.122
	机器人组	联合组	1.867	0.350	-2.122	5.856
ARAT	脑机接口组	机器人组	-0.800	0.695	-4.887	3.287
	脑机接口组	联合组	-1.933	0.345	-6.021	2.154
	机器人组	联合组	-1.133	0.579	-5.221	2.954
MBI	脑机接口组	机器人组	1.867	0.585	-4.981	8.714
	脑机接口组	联合组	-1.867	0.585	-8.714	4.981
	机器人组	联合组	-3.733	0.277	-10.581	3.114
DAR	脑机接口组	机器人组	0.109	0.791	-0.714	0.931
	脑机接口组	联合组	-0.077	0.850	-0.900	0.745
	机器人组	联合组	-0.186	0.650	-1.009	0.637

Effect of brain-computer interface combined with upper limb rehabilitation robot on upper limb function of stroke patients

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变量	组别	组别	均值差	P值	95%CI
变量	组别	组别	均值差	P值	下限	上限
FMA-UE	脑机接口组	机器人组	0.400	0.863	-4.245	5.045
	脑机接口组	联合组	-5.133	0.031	-9.779	-0.488
	机器人组	联合组	-5.533	0.021	-10.179	-0.888
ARAT	脑机接口组	机器人组	-0.133	0.944	-3.927	3.660
	脑机接口组	联合组	-4.533	0.020	-8.327	-0.740
	机器人组	联合组	-4.400	0.024	-8.193	-0.607
MBI	脑机接口组	机器人组	0.467	0.887	-6.111	7.044
	脑机接口组	联合组	-7.000	0.038	-13.578	-0.422
	机器人组	联合组	-7.467	0.027	-14.044	-0.889
DAR	脑机接口组	机器人组	-0.060	0.858	-0.731	0.611
	脑机接口组	联合组	0.803	0.020	0.132	1.473
	机器人组	联合组	0.863	0.013	0.192	1.533