Progress in Vascular Dementia Rat Model Induced by Bilateral Common Carotid Artery Ligation (review)

  • MENG Min ,
  • LI Lin
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  • Department of Pharmacology, Xuanwu Hospital, Capital Medical University; Beijing Engineering Research Center for Nervous System Drugs; Key Laboratory for Neurodegenerative Disease of Ministry of Education, Beijing 100053, China

Received date: 2017-11-08

  Revised date: 2018-01-24

  Online published: 2018-03-27

Supported by

Supported by Beijing Research and Development Plan (No. Z131102002813066; No. D0206001043191) and Beijing Health High Level Professional Plan (No. 2011-1-7)

Abstract

Rats after permanent bilateral common carotid artery ligation would result in cerebral blood flow reduction, learning and memory dysfunction, neuronal injury and death, synaptic and dendritic injury, and neuroinflammation, etc., which reproduce the pathology and clinical symptoms of human vascular dementia, that help for further research on pathophysiology and treatment of vascular dementia.

Cite this article

MENG Min , LI Lin . Progress in Vascular Dementia Rat Model Induced by Bilateral Common Carotid Artery Ligation (review)[J]. Chinese Journal of Rehabilitation Theory and Practice, 2018 , 24(3) : 309 -312 . DOI: 10.3969/j.issn.1006-9771.2018.03.012

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