Advance of Rab27a Gene and Exosomes (review)

  • WANG Xiao-xia ,
  • CHEN Yu-sen ,
  • MA Xiao-tang ,
  • PAN Qun-wen ,
  • HUANG Zi-hui
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  • 1. Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524002, China;
    2. Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524000, China

Received date: 2018-07-02

  Online published: 2018-10-30

Supported by

National Natural Science Foundation Youth Fund Project (No. 81701175) and Guangdong Sailing Plan Cultivates High-level Talent Project (No. 4YF17007G)

Abstract

Rab27a gene can participate in the secretion, transportation and exocytosis of T lymphocytes, mast cells, neutrophils, pancreatic β cells and hematopoietic cells through its encoded proteins, and participate in the development of diseases such as albinism, cancer, diabetes, inflammation and thrombosis. In addition, the secretion regulation of Rab27a to exosomes has also received much attention. The current research status of the secretion of exosome and the genetically modified exosomes of Rab27a gene in the treatment of diseases such as inflammatory injury, thrombosis and tumor were reviewed.

Cite this article

WANG Xiao-xia , CHEN Yu-sen , MA Xiao-tang , PAN Qun-wen , HUANG Zi-hui . Advance of Rab27a Gene and Exosomes (review)[J]. Chinese Journal of Rehabilitation Theory and Practice, 2018 , 24(10) : 1159 -1164 . DOI: 10.3969/j.issn.1006-9771.2018.10.008

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