Application of Magnetic Resonance Spectroscopy in Clinic (review)

  • LIU Jun ,
  • LI Jian-jun ,
  • GAO Feng ,
  • ZHANG Wen-hao ,
  • LIU Chang-bin ,
  • LI Jun ,
  • YANG De-gang ,
  • ZHANG Xin ,
  • ZHANG Chao ,
  • QIN Chuan
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  • 1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China
    2. Department of Spinal and Neural Function Reconstruction, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
    3. China Institute of Rehabilitation Science, Beijing 100068, China
    4. Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100068, China
    5. Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China
    6. Chinese Association of Rehabilitation Medicine, Beijing 100101, China

Received date: 2019-01-10

  Revised date: 2019-01-30

  Online published: 2019-04-01

Supported by

China Rehabilitation Research Center Project (No. 2018ZX-05)

Abstract

Magnetic resonance spectroscopy (MRS) can directly and quantitatively analyze tissue metabolism. In the field of rehabilitation, it has been used in the prognosis of spinal cord injury, and observation of the metabolic changes after injury; in the diagnosis of stroke, cognitive dysfunction assessment, and dystonia mechanism research; exploring the rehabilitation mechanism of Parkinson's disease. It can be used in tumors for auxiliary diagnosis of prostate cancer and brain tumors. In addition, it can be used to assess the severity and prognosis of heat stroke, and to study the pathogenesis of Duchenne muscular dystrophy and multiple system atrophy. It was found in the animal experiments that it can optimize the experimental design. With the development of advanced shimming algorithms and other technologies, the limitations of MRS will be gradually broken.

Cite this article

LIU Jun , LI Jian-jun , GAO Feng , ZHANG Wen-hao , LIU Chang-bin , LI Jun , YANG De-gang , ZHANG Xin , ZHANG Chao , QIN Chuan . Application of Magnetic Resonance Spectroscopy in Clinic (review)[J]. Chinese Journal of Rehabilitation Theory and Practice, 2019 , 25(2) : 201 -204 . DOI: 10.3969/j.issn.1006-9771.2019.02.013

References

[1] 曹亚先. MRI及1H-MRS对新生儿苍白球胆红素损伤的监测价值[D]. 广州: 南方医科大学, 2011.
[2] Scheau C, Preda E M, Popa G A, et al. Magnetic resonance spectroscopy—a non-invasive method in evaluating focal and diffuse central nervous system disease [J]. J Med Life, 2012, 5(4): 423-427.
[3] Erschbamer M, ?berg J, Westman E, et al. 1H-MRS in spinal cord injury: acute and chronic metabolite alterations in rat brain and lumbar spinal cord [J]. Eur J Neurosci, 2011, 33(4): 678-688.
[4] Tator C H, Fehlings M G. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms [J]. J Neurosurg, 1991, 75(1): 15-26.
[5] Ellingson B M, Salamon N, Hardy A J, et al. Prediction of neurological impairment in cervical spondylotic myelopathy using a combination of diffusion MRI and proton MR spectroscopy [J]. PLoS One, 2015, 10(10): e139451.
[6] Duetzmann S, Pilatus U, Seifert V, et al. Ex vivo 1H MR spectroscopy and histology after experimental chronic spinal cord compression [J]. J Spine Surg, 2017, 3(2): 176-183.
[7] 姜懿祥,徐晶,王如男,等.核磁共振波谱结合ADC值对亚急性期脑梗死的初步研究[J]. 黑龙江医药科学, 2018, 41(1): 57-58.
[8] Wang S Y, Wang M, Wang X X, et al. Study on the clinical application of the MRS in the cognitive assessment after stroke [J]. Eur Rev Med Pharmacol Sci, 2017, 21(10): 2437-2442.
[9] 张晓钰,杨帆,赵军,等.脑卒中肌张力增高与多巴胺神经递质水平关系的研究[J].国际神经精神科学杂志, 2017, 6(3): 32-38.
[10] Di Pancrazio L, Bellomo R G, Franciotti R, et al. Combined rehabilitation program for postural instability in progressive supranuclear palsy [J]. NeuroRehabilitation, 2013, 32(4): 855-860.
[11] Delli Pizzi S, Bellomo R G, Carmignano S M, et al. Rehabilitation program based on sensorimotor recovery improvesthe static and dynamic balance and modifies the basal ganglia neurochemistry [J]. Medicine, 2017, 96(50): e8732.
[12] Siegel R L, Miller K D, Jemal A. Cancer Statistics, 2018 [J]. CA Cancer J Clin, 2018, 68(1): 7-30.
[13] 陈友干.前列腺穿刺活检[J].国际泌尿系统杂志, 2011, 31(3): 346-351.
[14] Thompson J, Lawrentschuk N, Frydenberg M, et al. The role of magnetic resonance imaging in the diagnosis and management of prostate cancer [J]. BJU Int, 2013, 112(Suppl 2): 6-20.
[15] 梅亚军,姜黄维,金平,等.ASL MRS联合PSA在诊断前列腺癌及良性前列腺增生中的价[J].浙江临床医学, 2018, 20(6): 1017-1020.
[16] 郦俊生,程捷,沙键,等.ROC曲线分析波谱定量分析在前列腺癌中的诊断价值[J].现代肿瘤医学, 2011, 19(11): 2285-2287.
[17] 宋志强,杜向东,茹荷燕,等.磁共振波谱分析在前列腺癌临床评估中的价值[J].实用放射学杂志, 2016, 32(9): 1398-1401.
[18] Brandao L A, Shiroishi M S, Law M. Brain tumors: a multimodality approach with diffusion-weighted imaging, diffusion tensor imaging,magnetic resonance spectroscopy, dynamic susceptibility contrast and dynamic contrast-enhanced magnetic resonance imaging [J]. Magn Reson Imaging Clin N Am, 2013, 21(2): 199-239.
[19] Collet S, Valable S, Constans J M, et al.
[(18)F]-fluoro-L-thymidine PET and advanced MRI for preoperative grading of gliomas [J]. Neuroimage Clin, 2015, 8: 448-454.
[20] Faghih Jouibari M, Ghodsi S M, Akhlaghpoor S, et al. Complementary effect of H MRS in diagnosis of suprasellar tumors [J]. Clin Imaging, 2012, 36(6): 810-815.
[21] 李泉,卞佳,王萍,等.MRS对胼胝体病变的鉴别诊断价值[J].实用放射学杂志, 2017, 33(7): 985-987.
[22] 梁鸿,任明亮,姚一搏,等.MRI联合MRS辅助立体定向放射治疗复发高级别胶质瘤的疗效观察[J].重庆医学, 2018, 47(13): 1756-1757.
[23] 邹晗.热射病的治疗研究进展[J].中国急救复苏与灾害医学杂志, 2018, 13(9): 908-909.
[24] Li J, Zhang X Y, Zou Z M, et al. Heat stroke: typical MRI and 1H-MRS features [J]. Clin Imaging, 2015, 39(3): 504-505.
[25] Heier C R, Guerron A D, Korotcov A, et al. Non-invasive MRI and spectroscopy of mdx mice reveal temporal changes in dystrophic muscle imaging and in energy deficits [J]. PLoS One, 2014, 9(11): e112477.
[26] Graham J G, Oppenheimer D R. Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy [J]. J Neurol Neurosurg Psychiatry, 1969, 32(1): 28-34.
[27] 向小爽,侯漩,孙占芳,等.合并认知障碍的多系统萎缩患者磁共振氢质子波谱[J].中南大学学报(医学版), 2015, 40(6): 639-645.
[28] van Ewijk P A, Schrauwen-Hinderling V B, Bekkers S C, et al. MRS: a noninvasive window into cardiac metabolism [J]. NMR Biomed, 2015, 28(7): 747-766.
[29] 柏燕,张凯钟,张茜,等. MRI及MRS对新生儿急性胆红素脑病的诊断效能比较[J].中国中西医结合影像学杂志, 2017, 15(3): 270-273.
[30] 刘金,肖胜,武永康. MRS联合立体定向穿刺术治疗脑脓肿11例[J].中国临床神经外科杂志, 2018, 23(2): 105-107.
[31] 樊子健,张永波,鞠文萍,等. MRS在非海马硬化颞叶癫痫患者中的应用[J].中国医学影像技术, 2017, 33(9): 1326-1330.
[32] 余留森,马小静,张俊丽,等. PWI联合MRS在鞍旁海绵状血管瘤与脑膜瘤鉴别诊断中的价值[J].中国CT和MRI杂志, 2017, 15(8): 30-32.
[33] 毛宁,徐聪,王滨. 儿童、青少年抑郁症DTI及MRS的研究进展[J].医学影像学杂志, 2014, 33(3): 481-483.
[34] 肖慧,吴应行,倪萍,等. 阿尔茨海默病后扣带回磁共振波谱成像研究[J].中国医疗设备, 2014, 29(11): 11-14, 32.
[35] Ross B D. High-field MRS in clinical drug development [J]. Expert Opin Drug Discov, 2013, 8(7): 849-863.
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