Regulatory Role of Exercise-induced Autophagy in Rehabilitation of Sarcopenia (review)

  • LIANG Ji-ling ,
  • XIE Jin-feng ,
  • WANG Cen-yi ,
  • CHEN Ning
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  • 1.Graduate School, Wuhan Sports University, Wuhan, Hubei 430079, China
    2.John G. Rangos Sr. School of Health Sciences, Duquesne University, Pittsburgh PA15282, USA
    3.Tianjiu Research and Development Center for Exercise Nutrition and Foods, Hubei Key Laboratory of Sport Training and Monitoring, College of Health Science, Wuhan Sports University, Wuhan, Hubei 430079, China

Received date: 2018-08-31

  Revised date: 2018-10-19

  Online published: 2019-04-02

Supported by

National Natural Science Foundation of China (General) (No. 31571228), Hubei Sports Education and Health Promotion Discipline Group?Foundation and Hubei Scientific?and?Technological Innovation Team Program Foundation?for?Middle-aged?and?Young?Scientist (No. T201624)

Abstract

arcopenia is an aging-related disease with a significant reduction in mass and strength of skeletal muscle due to the imbalance between protein synthesis and degradation. Autophagy acts as a conserved mechanism regulating the balance of protein metabolism in body and can be regulated by multiple signaling pathways such as AMP-activated protein kinase (AMPK), insulin like growth factor (IGF)/ protein kinase B (Akt)/ mammalian target of rapamycin (mTOR) and phosphatidylinositol 3 kinase (PI3K)/Akt/mTOR induced by exercise. Exercise-activated autophagy regulates skeletal muscle remodeling and homeostasis under different physiological and pathological conditions, which is the key to skeletal muscle health maintenance. This article reviewed the regulator roles and potential molecular mechanisms of varying exercise-induced autophagy in the prevention, treatment and rehabilitation of sarcopenia.

Cite this article

LIANG Ji-ling , XIE Jin-feng , WANG Cen-yi , CHEN Ning . Regulatory Role of Exercise-induced Autophagy in Rehabilitation of Sarcopenia (review)[J]. Chinese Journal of Rehabilitation Theory and Practice, 2019 , 25(3) : 334 -337 . DOI: 10.3969/j.issn.1006-9771.2019.03.015

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