《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2019, Vol. 25 ›› Issue (7): 822-827.doi: 10.3969/j.issn.1006-9771.2019.07.016

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Effect of Enteral Nutrition on Intestinal Flora in Patients with Ischemic Stroke

FAN Chun-jiang1, LIU Ting-yu2, LI Gang1, HUANG Jian1, CAO Yang1, DANG Yi-ni3   

  1. 1.Department of Rehabilitation, Wuxi Rehabilitation Hospital (Wuxi Rehabilitation Center for the Disabled), Wuxi, Jiangsu 214043, China
    2.Department of Gastroenterology, Qingpu Branch, Affiliated Zhongshan Hospital of Fudan University, Shanghai 201799, China
    3.Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing, Jiangsu 210029, China
  • Received:2019-02-11 Revised:2019-04-19 Published:2019-07-25 Online:2019-07-23
  • Contact: DANG Yi-ni E-mail:yeani-hi@126.com
  • Supported by:
    Supported by Wuxi Health and Family Planning Bureau Project (General) (No. ME201504)

Abstract: Objective To explore the effect of enteral nutrition on gut microbiota for ischemic stroke. Methods From March to April, 2017, 121 patients with convalescent ischemic stroke were enrolled. The patients received routine rehabilitation combing with 1-week enteral nutrition. The patients' fresh feces and blood samples were obtained at admission, one week and one month after the enteral nutrition, while nutritional status was assessed with Nutrition Risk Screening (NRS2002). Cytokines, including tumor necrosis factor (TNF) -α, interleukin (IL)-1α, IL-1β, IL-6 and IL-8 were tested with ELISA. Ten patients were tested with 16S rDNA Illumina HiSeq/MiSeq for gut microbiota alterations. Results The scores of NRS2002 decreased (P < 0.05), the level of serum IL-1β and IL-6 raised, while the level of IL-8 dropped one month after enteral nutrition (P < 0.05). In addition, the enteral nutrition altered the dominant bacterial community, and alleviated the diversity and species richness of bacteria, while the difference was statistically significant one week after enteral nutrition. Conclusion Enteral nutrition can alter gut microbiota to facilitate to recover ischemic stroke.

Key words: ischemic stroke, enteral nutrition, intestinal flora

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