《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2021, Vol. 27 ›› Issue (12): 1450-1457.doi: 10.3969/j.issn.1006-9771.2021.12.011
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Received:
2021-06-20
Revised:
2021-11-09
Published:
2021-12-25
Online:
2021-12-29
Contact:
XU Xin
E-mail:xuxin@sus.edu.cn
Supported by:
CLC Number:
LIU Yu-chang,XU Xin. Effect of Combination of Regenerative Medicine and Rehabilitation on Motor Function of Neurological Diseases: A Scoping Review[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(12): 1450-1457.
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研究 | 国家 | 研究对象 | 再生疗法 | 康复治疗 | 干预效果(运动功能) | 可能机制 |
---|---|---|---|---|---|---|
Weishaupt等[ | 加拿大 | Lewis大鼠(n = 46) 颈段脊髓损伤 | 神经营养因子注射 | 任务导向性功能训练 | 联合干预组肢体功能改善显著 | 不明 |
Zhang等[ | 中国 | Sprague-Dawley大鼠(n = 60) 脑卒中 | 大鼠间充质干细胞移植 | 跑台训练 | 联合干预组神经行为功能明显改善 | 细胞凋亡减少; 干细胞存活增加 |
Sasaki等[ (2016) | 日本 | Sprague-Dawley大鼠(n = 40) 脑卒中 | 大鼠间充质干细胞移植 | 跑台训练 | 联合干预组运动功能显著改善 | 病灶面积减小; 胼胝体厚度增加; 突触发生增加 |
Tashiro等[ | 日本 | C57BL/6J小鼠(n = 80) 慢性胸段脊髓损伤 | 神经干细胞/祖细胞移植 | 跑台训练 | 联合干预组运动功能恢复显著改善(步态、痉挛程度) | 神经元分化增加; 中枢模式发生器成熟增加 |
Song等[ | 中国 | Sprague-Dawley大鼠(n = 30) 坐骨神经损伤 | 神经导管移植 | 电刺激 | 不明 | BDNF、GDNF、NT-3升高,神经再生增加 |
Akhoundzadeh等[ | 伊朗 | C57BL/6J小鼠 脑卒中 | 骨髓间充质干细胞移植和甲状腺激素注射 | 跑台训练 | 联合干预组神经行为功能明显改善 | 神经元凋亡减少, 脑梗死面积减少 |
Kim等[ (2017) | 韩国 | Sprague-Dawley大鼠(n = 40) T9~T10节段脊髓损伤 | 骨髓间充质干细胞移植 | 跑台训练 | 联合干预组BBB评分显著升高 | BDNF、突触素Ⅰ升高 |
Zhao等[ | 中国 | Sprague-Dawley大鼠(n = 170) 脑卒中 | 大鼠脂肪干细胞移植 | 低温治疗(33 ℃) | 不明 | 梗死面积、细胞凋亡减少、炎症反应、胶质瘢痕形成减少 血管生成增加 |
Morimoto等[ | 日本 | Wistar大鼠(n = 18) 脑卒中 | 大鼠间充质干细胞移植 | 电刺激(100 µA, 100 Hz) | 联合干预组行为测试结果显著改善 | 梗死面积减少, 移植细胞迁移增多,SDF-1α增加 |
Du等[ (2018) | 美国 | 无胸腺裸鼠(n = 60) 坐骨神经损伤 | 神经嵴干细胞移植 | 电刺激 | 联合干预组步态恢复显著改善 | 腓肠肌湿重增加,干细胞、施万细胞分化增加,神经再生增多 |
Tashiro等[ | 日本 | C57BL/6J小鼠(n = 55) 腰段脊髓损伤 | 神经干细胞/祖细胞移植 | 跑台训练 | 没有显著性改善 | 不明 |
Cucarián等[ | 巴西 | Wistar大鼠 (n = 41) 帕金森病 | 骨髓间充质干细胞移植到纹状体 | 跑台训练 | 单独运动组和联合治疗组在运动功能恢复方面均有显著改善。 | 不明 |
Lin等[ (2019) | 新加坡 | Sprague-Dawley大鼠(n = 26) 腰段脊髓损伤 | 生物支架植入 | 步态训练 | 联合干预组踝关节屈肌力量显著升高 | 轴突再生增多,抗炎细胞浓度升高 |
Mu等[ (2019) | 中国 | Sprague-Dawley大鼠(n = 97) 脑卒中 | 人脂肪组织源性间充质干细胞移植 | 丰富环境 | 联合干预组大鼠前肢功能显著改善 | 不清楚 |
研究 | 国家 | 研究对象 | 再生疗法 | 康复治疗 | 干预效果(运动功能) | 可能机制 |
Peng等[ | 中国 | Sprague-Dawley大鼠(n = 60) 脑卒中 | 神经干细胞移植 | 重复经颅磁刺激(10 Hz、300脉冲/d) | 显著改善脑卒中后的功能恢复 | 神经分化增加,BNDF升高 |
Zhu等[ | 中国 | 家兔(n = 40) 坐骨神经损伤 | 富血小板血浆注射 | 低剂量超短波 | 不明 | 轴突再生增加,肌肉萎缩减少 |
贾杰等[ | 中国 | Sprague-Dawley大鼠(n = 30) 脑卒中 | 神经干细胞移植 | 跑台训练 | 联合干预组神经行为评分显著改善 | 神经干细胞迁移、分化、存活率增加 |
周治来等[ | 中国 | Sprague-Dawley大鼠(n = 40) T10脊髓损伤 | 骨髓源性神经干细胞移植 | 康复训练(跑台、滚筒) | 联合干预组BBB评分显著升高 | 神经干细胞存活率、分化率增加 |
周治来等[ | 中国 | Sprague-Dawley大鼠(n = 80) T10脊髓损伤 | 神经干细胞移植 | 康复训练(跑台、滚筒) | 联合干预组BBB 评分显著升高 | Nogo-A、NgR下降 |
张鑫等[ | 中国 | Sprague-Dawley大鼠(n = 100) T10节段不完全脊髓损伤 | 人脂肪间充质干细胞移植 | 康复训练(跑台、滚筒) | 联合干预组BBB评分结果显著升高 | BNDF升高 |
介小素等[ | 中国 | Sprague-Dawley大鼠(n = 51) 脑瘫 | 神经干细胞移植 | 针灸 | 联合干预组行为学评分显著改善 | 神经细胞凋亡减少 |
武玉江[ | 中国 | Sprague-Dawley大鼠(n = 60) 脊髓损伤 | 神经干细胞移植 | 早期运动训练(跑台、滚筒) | 联合干预组BBB评分及斜板实验评分显著升高 | caspase-3下降,髓过氧化物酶下降 |
赵素香等[ | 中国 | Sprague-Dawley大鼠(n = 80) 脊髓损伤 | 内皮祖细胞移植 | 早期运动训练(跑台、滚筒) | 联合干预组改良的Tarlov评分、BBB评分及斜板实验评分显著升高 | 神经突触再增加,血管再生增加 |
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