再生疗法和康复治疗的联合应用对神经疾病运动功能的康复效果：Scoping综述

doi:10.3969/j.issn.1006-9771.2021.12.011

Abstract

Abstract:

Objective To perform a scoping review of the combination of regenerative therapy and rehabilitation in neurological diseases.Methods Literatures about the combination of regenerative therapy and rehabilitation in neurological diseases were retrieved in PubMed, Web of Science, CNKI and Wanfang data from establishment to April 1st, 2021.Results A total of 2567 literatures were retrieved, and 26 were finally enrolled, including three human clinical studies and 23 animal basic studies. The research design was mainly randomized or non-randomized controlled trials and case series. The researches mainly involved the therapeutic effect of combined regeneration therapy and rehabilitation on neurological diseases, such as stroke, spinal cord injury and cerebral palsy, etc.Conclusion The researches and applications of regenerative rehabilitation in neurological diseases were scoped, and it was found that the combination of regenerative therapy and rehabilitation has synergistic effects on the restoration of motor function of neurological diseases, and more scientific researches are needed to support its clinical practice in the future.

Key words: regenerative medicine, cell therapy, regenerative rehabilitation, physical therapy, motor function, nervous system diseases, scoping review

CLC Number:

R741

LIU Yu-chang,XU Xin. Effect of Combination of Regenerative Medicine and Rehabilitation on Motor Function of Neurological Diseases: A Scoping Review[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(12): 1450-1457.

Figures/Tables 3

研究	国家	研究对象	再生疗法	康复治疗	干预效果(运动功能)	可能机制
Weishaupt等^[15](2013)	加拿大	Lewis大鼠(n = 46) 颈段脊髓损伤	神经营养因子注射	任务导向性功能训练	联合干预组肢体功能改善显著	不明
Zhang等^[9](2015)	中国	Sprague-Dawley大鼠(n = 60) 脑卒中	大鼠间充质干细胞移植	跑台训练	联合干预组神经行为功能明显改善	细胞凋亡减少; 干细胞存活增加
Sasaki等^[16] (2016)	日本	Sprague-Dawley大鼠(n = 40) 脑卒中	大鼠间充质干细胞移植	跑台训练	联合干预组运动功能显著改善	病灶面积减小; 胼胝体厚度增加; 突触发生增加
Tashiro等^[17](2016)	日本	C57BL/6J小鼠(n = 80) 慢性胸段脊髓损伤	神经干细胞/祖细胞移植	跑台训练	联合干预组运动功能恢复显著改善(步态、痉挛程度)	神经元分化增加; 中枢模式发生器成熟增加
Song等^[18](2016)	中国	Sprague-Dawley大鼠(n = 30) 坐骨神经损伤	神经导管移植	电刺激	不明	BDNF、GDNF、NT-3升高,神经再生增加
Akhoundzadeh等^[19](2017)	伊朗	C57BL/6J小鼠脑卒中	骨髓间充质干细胞移植和甲状腺激素注射	跑台训练	联合干预组神经行为功能明显改善	神经元凋亡减少, 脑梗死面积减少
Kim等^[20] (2017)	韩国	Sprague-Dawley大鼠(n = 40) T₉~T₁₀节段脊髓损伤	骨髓间充质干细胞移植	跑台训练	联合干预组BBB评分显著升高	BDNF、突触素Ⅰ升高
Zhao等^[21](2018)	中国	Sprague-Dawley大鼠(n = 170) 脑卒中	大鼠脂肪干细胞移植	低温治疗(33 ℃)	不明	梗死面积、细胞凋亡减少、炎症反应、胶质瘢痕形成减少血管生成增加
Morimoto等^[22](2018)	日本	Wistar大鼠(n = 18) 脑卒中	大鼠间充质干细胞移植	电刺激(100 µA, 100 Hz)	联合干预组行为测试结果显著改善	梗死面积减少, 移植细胞迁移增多,SDF-1α增加
Du等^[23] (2018)	美国	无胸腺裸鼠(n = 60) 坐骨神经损伤	神经嵴干细胞移植	电刺激	联合干预组步态恢复显著改善	腓肠肌湿重增加,干细胞、施万细胞分化增加,神经再生增多
Tashiro等^[24](2018)	日本	C57BL/6J小鼠(n = 55) 腰段脊髓损伤	神经干细胞/祖细胞移植	跑台训练	没有显著性改善	不明
Cucarián等^[25](2019)	巴西	Wistar大鼠 (n = 41) 帕金森病	骨髓间充质干细胞移植到纹状体	跑台训练	单独运动组和联合治疗组在运动功能恢复方面均有显著改善。	不明
Lin等^[26] (2019)	新加坡	Sprague-Dawley大鼠(n = 26) 腰段脊髓损伤	生物支架植入	步态训练	联合干预组踝关节屈肌力量显著升高	轴突再生增多,抗炎细胞浓度升高
Mu等^[27] (2019)	中国	Sprague-Dawley大鼠(n = 97) 脑卒中	人脂肪组织源性间充质干细胞移植	丰富环境	联合干预组大鼠前肢功能显著改善	不清楚
研究	国家	研究对象	再生疗法	康复治疗	干预效果(运动功能)	可能机制
Peng等^[10] (2019)	中国	Sprague-Dawley大鼠(n = 60) 脑卒中	神经干细胞移植	重复经颅磁刺激(10 Hz、300脉冲/d)	显著改善脑卒中后的功能恢复	神经分化增加,BNDF升高
Zhu等^[11] (2020)	中国	家兔(n = 40) 坐骨神经损伤	富血小板血浆注射	低剂量超短波	不明	轴突再生增加,肌肉萎缩减少
贾杰等^[28] (2008)	中国	Sprague-Dawley大鼠(n = 30) 脑卒中	神经干细胞移植	跑台训练	联合干预组神经行为评分显著改善	神经干细胞迁移、分化、存活率增加
周治来等^[29](2010)	中国	Sprague-Dawley大鼠(n = 40) T₁₀脊髓损伤	骨髓源性神经干细胞移植	康复训练(跑台、滚筒)	联合干预组BBB评分显著升高	神经干细胞存活率、分化率增加
周治来等^[30] (2010)	中国	Sprague-Dawley大鼠(n = 80) T₁₀脊髓损伤	神经干细胞移植	康复训练(跑台、滚筒)	联合干预组BBB 评分显著升高	Nogo-A、NgR下降
张鑫等^[31] (2014)	中国	Sprague-Dawley大鼠(n = 100) T₁₀节段不完全脊髓损伤	人脂肪间充质干细胞移植	康复训练(跑台、滚筒)	联合干预组BBB评分结果显著升高	BNDF升高
介小素等^[32] (2015)	中国	Sprague-Dawley大鼠(n = 51) 脑瘫	神经干细胞移植	针灸	联合干预组行为学评分显著改善	神经细胞凋亡减少
武玉江^[33](2016)	中国	Sprague-Dawley大鼠(n = 60) 脊髓损伤	神经干细胞移植	早期运动训练(跑台、滚筒)	联合干预组BBB评分及斜板实验评分显著升高	caspase-3下降,髓过氧化物酶下降
赵素香等^[34](2016)	中国	Sprague-Dawley大鼠(n = 80) 脊髓损伤	内皮祖细胞移植	早期运动训练(跑台、滚筒)	联合干预组改良的Tarlov评分、BBB评分及斜板实验评分显著升高	神经突触再增加,血管再生增加

References 41

[1]	GOOCH C L, PRACHT E, BORENSTEIN A R. The burden of neurological disease in the United States: a summary report and call to action[J]. Ann Neurol, 2017, 81(4):479-484. doi: 10.1002/ana.24897
[2]	LIN D J, FINKLESTEIN S P, CRAMER S C. New directions in treatments targeting stroke recovery[J]. Stroke, 2018, 49(12):3107-3114. doi: 10.1161/STROKEAHA.118.021359
[3]	LANGHORNE P, BERNHARDT J, KWAKKEL G. Stroke rehabilitation[J]. Lancet, 2011, 377(9778):1693-1702. doi: 10.1016/S0140-6736(11)60325-5
[4]	AMBROSIO F, RUSSELL A. Regenerative rehabilitation: a call to action [J]. J Rehabil Res Dev, 2010, 47(3): xi-xv.
[5]	HEAD P L. Rehabilitation considerations in regenerative medicine[J]. Phys Med Rehabil Clin N Am, 2016, 27(4):1043-1054. doi: 10.1016/j.pmr.2016.07.002
[6]	ROSE L F, WOLF E J, BRINDLE T, et al. The convergence of regenerative medicine and rehabilitation: federal perspectives[J]. NPJ Regen Med, 2018, 3:19. doi: 10.1038/s41536-018-0056-1
[7]	陈红, 黄晓琳. 再生康复医学:康复医学的新领域[J]. 中华物理医学与康复杂志, 2015, 37(5):384.
	CHEN H, HUANG X L. Regenerative rehabilitation: a new field of rehabilitation medicine[J]. Chin J Phys Med Rehabil, 2015, 37(5):384.
[8]	RANDO T A, AMBROSIO F. Regenerative rehabilitation: applied biophysics meets stem cell therapeutics[J]. Cell Stem Cell, 2018, 22(3):306-309. doi: 10.1016/j.stem.2018.02.003
[9]	ZHANG Y X, YUAN M Z, CHENG L, et al. Treadmill exercise enhances therapeutic potency of transplanted bone mesenchymal stem cells in cerebral ischemic rats via anti-apoptotic effects[J]. BMC Neurosci, 2015, 16:56. doi: 10.1186/s12868-015-0196-9
[10]	PENG J J, SHA R, LI M X, et al. Repetitive transcranial magnetic stimulation promotes functional recovery and differentiation of human neural stem cells in rats after ischemic stroke[J]. Exp Neurol, 2019, 313:1-9. doi: 10.1016/j.expneurol.2018.12.002
[11]	ZHU Y Q, JIN Z, FANG J, et al. Platelet-rich plasma combined with low-dose ultrashort wave therapy accelerates peripheral nerve regeneration[J]. Tissue Engineering Part A, 2020, 26(3-4):178-192. doi: 10.1089/ten.tea.2019.0187
[12]	WAHL A S, OMLOR W, RUBIO J C, et al. Neuronal repair. asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke[J]. Science, 2014, 344(6189):1250-1255. doi: 10.1126/science.1253050
[13]	BOLTZE J, MODO M M, MAYS R W, et al. Stem cells as an emerging paradigm in stroke 4: advancing and accelerating preclinical research[J]. Stroke, 2019, 50(11):3299-3306. doi: 10.1161/STROKEAHA.119.025436
[14]	ARKSEY H, O'MALLEY L. Scoping studies: towards a methodological framework[J]. Int J Social Res Methodol, 2005, 8(1):19-32. doi: 10.1080/1364557032000119616
[15]	WEISHAUPT N, LI S, DI PARDO A, et al. Synergistic effects of BDNF and rehabilitative training on recovery after cervical spinal cord injury[J]. Behav Brain Res, 2013, 239:31-42. doi: 10.1016/j.bbr.2012.10.047
[16]	SASAKI Y, SASAKI M, KATAOKA-SASAKI Y, et al. Synergic effects of rehabilitation and intravenous infusion of mesenchymal stem cells after stroke in rats[J]. Phys Ther, 2016, 96(11):1791-1798. doi: 10.2522/ptj.20150504
[17]	TASHIRO S, NISHIMURA S, IWAI H, et al. Functional recovery from neural stem/progenitor cell transplantation combined with treadmill training in mice with chronic spinal cord injury[J]. Sci Rep, 2016, 6:30898. doi: 10.1038/srep30898
[18]	SONG J, SUN B, LIU S, et al. Polymerizing pyrrole coated poly (l-lactic acid-co-ε-caprolactone) (PLCL) conductive nanofibrous conduit combined with electric stimulation for long-range peripheral nerve regeneration[J]. Front Mol Neurosci, 2016, 9:117.
[19]	AKHOUNDZADEH K, VAKILI A, SAMENI H R, et al. Effects of the combined treatment of bone marrow stromal cells with mild exercise and thyroid hormone on brain damage and apoptosis in a mouse focal cerebral ischemia model[J]. Metab Brain Dis, 2017, 32(4):1267-1277. doi: 10.1007/s11011-017-0034-0
[20]	KIM Y M, SEO T B, KIM C J, et al. Treadmill exercise with bone marrow stromal cells transplantation potentiates recovery of locomotor function after spinal cord injury in rats[J]. J Exerc Rehabil, 2017, 13(3):273-278. doi: 10.12965/jer.1735014.507
[21]	ZHAO K, LI R, BI S, et al. Combination of mild therapeutic hypothermia and adipose-derived stem cells for ischemic brain injury[J]. Neural Regen Res, 2018, 13(10):1759-1770. doi: 10.4103/1673-5374.238617
[22]	MORIMOTO J, YASUHARA T, KAMEDA M, et al. Electrical stimulation enhances migratory ability of transplanted bone marrow stromal cells in a rodent ischemic stroke model[J]. Cell Physiol Biochem, 2018, 46(1):57-68. doi: 10.1159/000488409
[23]	DU J, ZHEN G, CHEN H, et al. Optimal electrical stimulation boosts stem cell therapy in nerve regeneration[J]. Biomaterials, 2018, 181:347-359. doi: 10.1016/j.biomaterials.2018.07.015
[24]	TASHIRO S, NISHIMURA S, SHINOZAKI M, et al. The amelioration of pain-related behavior in mice with chronic spinal cord injury treated with neural stem/progenitor cell transplantation combined with treadmill training[J]. J Neurotrauma, 2018, 35(21):2561-2571. doi: 10.1089/neu.2017.5537
[25]	CUCARIÁN J D, BERRÍO J P, RODRIGUES C, et al. Physical exercise and human adipose-derived mesenchymal stem cells ameliorate motor disturbances in a male rat model of Parkinson's disease[J]. J Neurosci Res, 2019, 97(9):1095-1109. doi: 10.1002/jnr.v97.9
[26]	LIN J, ANOPAS D, MILBRETA U, et al. Regenerative rehabilitation: exploring the synergistic effects of rehabilitation and implantation of a bio-functional scaffold in enhancing nerve regeneration[J]. Biomater Sci, 2019, 7(12):5150-5160. doi: 10.1039/C9BM01095E
[27]	MU J, BAKREEN A, JUNTUNEN M, et al. Combined adipose tissue-derived mesenchymal stem cell therapy and rehabilitation in experimental stroke[J]. Front Neurol, 2019, 10:235. doi: 10.3389/fneur.2019.00235
[28]	贾杰, 胡永善, 吴毅, 等. 跑台运动训练促进脑梗死大鼠外源性移植的神经干细胞迁移分化的实验研究[J]. 中国康复医学杂志, 2008, 23(7):594-597.
	JIA J, HU Y S, WU Y, et al. Experimental study of the effects of treadmill training on promoting transplanted neural stem cell migration and differentiation in rat′s brain after cerebral infarction[J]. Chin J Rehabi Med, 2008, 23(7):594-597.
[29]	周治来, 陈银海, 闵少雄. 康复训练对脊髓损伤大鼠外源性移植的骨髓源性神经干细胞的影响[J]. 实用医学杂志, 2011, 27(17):3103-3106.
	ZHOU Z L, CHEN Y H, MIN S X, et al. Experimental study of the effects of rehabilitation training on transplanted BMSC-D-NSCs in rats with spinal cord injury[J]. J Pract Med, 2011, 27(17):3103-3106.
[30]	周治来, 靳安民, 陈银海, 等. 神经干细胞移植联合康复训练对脊髓损伤大鼠Nogo-A及NgR蛋白表达的影响[J]. 中华物理医学与康复杂志, 2011, 33(8):566-570.
	ZHOU Z L, JIN A M, CHEN Y H, et al. Effect of neural stem cell transplantation combined with rehabilitation training on Nogo-A and NgR protein expression in rats with spinal cord injury[J]. Chin J Phys Med Rehabil, 2011, 33(8):566-570.
[31]	张鑫, 李萌, 陈银海, 等. hADSCs移植联合运动训练对脊髓损伤大鼠运动功能的影响及其相关机制[J]. 中华神经医学杂志, 2014, 13(5):472-477.
	ZHANG X, LI M, CHEN Y H, et al. Effects of hADSCs transplantation combined with exercise training on the motor function of rats with spinal cord injury and its related mechanisms[J]. Chin J Neurol Med, 2014, 13(5):472-477.
[32]	介小素, 侯玉晋. 针刺联合神经干细胞移植对脑性瘫痪幼鼠模型的作用机制[J]. 中国组织工程研究, 2015, 19(45):7309-7313.
	JIE X S, HOU Y J. Combined therapy of acupuncture and neural stem cell transplantation in immature rats with cerebral palsy[J]. Chin J Tiss Eng Res, 2015, 19(45):7309-7313.
[33]	武玉江, 侯英诺, 张子檀, 等. 早期运动训练联合神经干细胞移植对脊髓损伤模型大鼠后肢运动功能的影响[J]. 中国组织工程研究, 2016, 20(6):876-882.
	WU Y J, HOU Y N, ZHANG Z T, et al. Early exercise training combined with neural stem cell transplantation improves hindlimb motor function after spinal cord injury in rats[J]. Chin J Tiss Eng Res, 2016, 20(6):876-882.
[34]	赵素香, 侯英诺, 张子檀, 等. 内皮祖细胞移植联合早期运动改善脊髓损伤区血管再生及后肢功能[J]. 中国组织工程研究, 2016, 20(6):883-890.
	ZHAO S X, HOU Y N, HANG Z T, et al. Endothelial progenitor cell transplantation combined with early exercise training for spinal cord injury: improvement in hindlimb function and angiogenesis in the injured region[J]. Chin J Tiss Eng Res, 2016, 20(6):883-890.
[35]	LARSON C A, DENSION P M. Effectiveness of intense, activity-based physical therapy for individuals with spinal cord injury in promoting motor and sensory recovery: is olfactory mucosa autograft a factor?[J]. J Spinal Cord Med, 2013, 36(1):44-57. doi: 10.1179/2045772312Y.0000000026
[36]	袁进国, 冯斌, 曹藏柱, 等. 脐带间充质干细胞移植并康复治疗脑出血后遗症1年随访[J]. 中国组织工程研究, 2012, 16(14):2656-2660.
	YUAN J G, FENG B, CAO C Z, et al. Umbilical cord mesenchymal stem cell transplantation and rehabilitation treatment for cerebral hemorrhage sequela:1 year follow-up[J]. Chin J Tiss Eng Res, 2012, 16(14):2656-2660.
[37]	徐远红, 王俊华, 李海峰, 等. 脐带间充质干细胞移植联合综合康复训练对脊髓损伤患者神经功能及功能独立性的影响[J]. 中国康复医学杂志, 2015, 30(8):828-830.
	XU Y H, WANG J H, LI H F, et al. Effects of umbilical cord mesenchymal stem cell transplantation combined with comprehensive rehabilitation training on neurological function and functional independence in patients with spinal cord injury[J]. Chin J Rehabil Med, 2015, 30(8):828-830.
[38]	DENG Y H, DONG L L, ZHANG Y J, et al. Enriched environment boosts the post-stroke recovery of neurological function by promoting autophagy[J]. Neural Regen Res, 2021, 16(5):813-819. doi: 10.4103/1673-5374.297084
[39]	POLGAR S, BORLONGAN C V, KOUTOUZIS T K, et al. Implications of neurological rehabilitation for advancing intracerebral transplantation[J]. Brain Res Bull, 1997, 44(3):229-232. doi: 10.1016/S0361-9230(97)00109-3
[40]	WILLETT N J, BONINGER M L, MILLER L J, et al. Taking the next steps in regenerative rehabilitation: establishment of a new interdisciplinary field[J]. Arch Phys Med Rehabil, 2020, 101(5):917-923. doi: 10.1016/j.apmr.2020.01.007
[41]	邱卓英, 郭键勋, 李伦, 等. 世界卫生组织康复指南«健康服务体系中的康复»:背景、理论架构与方法、主要内容和实施[J]. 中国康复理论与实践, 2020, 26(1):16-20.
	QIU Z Y KOWK J K F LI L, et al. WHO Rehabilitation in Health System: background, framework and approach, contents and implementation[J]. Chin J Rehabil Theory Pract, 2020, 26(1):16-20.

Effect of Combination of Regenerative Medicine and Rehabilitation on Motor Function of Neurological Diseases: A Scoping Review

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研究	国家	研究对象	再生疗法	康复治疗	干预效果(运动功能)	可能机制
Larso等^[35](2013)	美国	脊髓损伤(n = 23)	椎管内嗅鞘细胞移植后	137.3小时的高强度综合康复训练	联合干预组与单独进行高强度锻炼组在运动功能的恢复方面没有显著性差异	不明
袁进国等^[36](2012)	中国	脑卒中(n = 45)	脐带间充质干细胞移植	综合康复训练	联合干预组肢体运动功能及日常生活活动能力均明显改善	病灶范围减小
徐远红等^[37](2015)	中国	脊髓损伤恢复期患者(n = 60)	脐带间充质干细胞移植	综合康复训练	联合治疗组功能独立性改善显著	不明

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