Objective To evaluate the efficacy of pregabalin combined with nerve block on postherpetic neuralgia (PHN). Methods 60patients were assigned into group A (n=30), who received pregabalin orally, and group B (n=30), who received nerve block (trigeminalnerve, intercostal nerve, lumbar nerve block) in addition. They were assessed with visual analogue scale (VAS) of pain, sleep score fromHamilton Rating Scale for Depression before and 3 d, 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks, 6 weeks, 7 weeks, and 8 weeks aftertreatment. The incidence of pain decreased >50% and >30% were compared. Results The scores of VAS and sleep significantly reduced inboth groups 1~8 weeks after treatment (P<0.01), and decreased significantly 3 d after treatment in group B than in group A (P<0.05). The incidenceof pain decreased >50% and >30% were more in group B than in group A (P<0.05). Conclusion Nerve block combined with oralpregabalin is more effective on PHN.

Rab27a gene can participate in the secretion, transportation and exocytosis of T lymphocytes, mast cells, neutrophils, pancreatic β cells and hematopoietic cells through its encoded proteins, and participate in the development of diseases such as albinism, cancer, diabetes, inflammation and thrombosis. In addition, the secretion regulation of Rab27a to exosomes has also received much attention. The current research status of the secretion of exosome and the genetically modified exosomes of Rab27a gene in the treatment of diseases such as inflammatory injury, thrombosis and tumor were reviewed.

This article reviewed the literatures on brain plastic reorganization theory, time of treatment, Methods and techniques of rehabilitation treatment, which inclued Bobath, Brunnstrom, Rood, PNF, MRP, biofeedback electrical stimulation therapy, constraint induced movement therapy, nerve muscle electrical stimulation therapy, acupuncture, body weight support treadmill training, motor imagery therapy, robot assisted therapy, and comprehensive rehabilitation therapy. It can provide theory basis and technique for early rehabilitation treatment after stroke.

Family resilience explores the positive resources of a family under adversity. This paper expounded the origin, concept, related factors, framework and implications of family resilience, especially the family resilience in families with a cancer patient.

Electroacupuncture preconditioning can alleviate the nerve defect after cerebral ischemia injury, induce cerebral ischemic tolerance and exert the certain protective effect on brain, which may be involved in regulating endocannabinoid system, inhibiting exitotoxicity, inhibiting oxidative stress, inhibiting endoplasmic reticulum stress, inhibiting inflammatory response, protecting blood-brain barrier, inhibiting apoptosis and regulating autophagy, etc.

Objective To constitute the short form of Wechsler Intelligence Scale for Children (WISC). Methods After selecting 6 subtests by regression, this study was based on the development of the Chinese Version of the 6 Subtests Short Form of WISC-Ⅳ based on the　data derived from the norm sample via the norm method and equation procedure. Results and Conclusion The best structure of the 6 subtests short form of WISC-Ⅳ consists of 6 subtests: similarities, comprehension, block design, matrix reasoning, digit span and coding, in which the reliability and validity were excellent. The results of division for children of intellectual disabilities is close to that of the full Chinese Version of WISC-Ⅳ.

Intestinal flora plays an important role in the process of human health and disease conversion. It not only participates in a number of physiological processes in the host, but also affects the central nervous system (CNS) -related diseases, which may involve in neurotransmitter, immune, endocrine, metabolites, etc. Intestinal dysbacteriosis plays a role in the development of CNS diseases, such as ischemic brain injury, Parkinson's disease, Alzheimer's disease, multiple sclerosis, hepatic encephalopathy, and mental disorders, etc. Fecal microbes transplantation, exercise training, acupuncture and Tuina therapy can improve the intestinal flora balance, which may be potential for the treatment and prevention of some nervous system diseases.

Objective To discuss the modification of the ASIA scale (version 2011) and the significance for clinical practice. Methods Through comparing the newest English version of ASIA scale to the previous version, we tried to find the difference between them and interpret the possible influence on clinical practice. Results The study found that there were 15 modifications found after comparing the two versions of scales. Some modifications were just descriptive, some were for emphasis, and the others were fundamental modification. Conclusion The ASIA Committee makes prudent modification according to the advice of the doctors worldwide in the past ten years to make scale more applicable for clinical practice. The modification will influence the neurological examination of spinal cord injuries in clinical practice and relative research

ObjectiveTo investigate methods of early postoperative rehabilitation and its effects on patients with bicondylar tibial plateau fracture treated by modified dual plating.Methods66 patients with bicondylar tibial plateau fracture from Tianjin Hospital were divided into 2 groups according to the starting time for postoperative rehabilitation: early rehabilitation group (n=30), convalescents rehabilitation group (n=36). The two groups had the same treatment since the fourth week postoperative. Tibial plateau angle (TPA) and posterior slope angle (PA) of tibial plateau were measured to evaluate the stability of proximal tibial and knee alignment. The Hospital for Special Surgery (HSS) score system and knee joint range of motion (ROM) were used as the parameters for knee function.ResultsThe mean value of TPA and PA had no significant changes, compared to the final follow-up and postoperative X-ray films(P>0.05); the differences between the two groups were statistically significant in the mean HSS score and mean value of knee flexion and extention ROM(P<0.01 or 0.05). There was significantly positive correlation between starting time and the total number of treatment was significant(P<0.01), while negative correlation with flexion ROM of knee joint and the HSS score(P<0.01).ConclusionThe correlation between rehabilitation intervention timing and functional recovery for patients with bicondylar tibial plateau fracture treated by modified dual plating is significant, early individual and systematic rehabilitation therapy can effectively improve the prognosis features of patients.

Upper limb lymphedema is one of the most common complications secondary to breast cancer surgery. Detailed medical history inquiry, careful physical examination, and precise and objective measurement are indispensable to accurately diagnose and evaluate upper limb lymphedema. The mostly widely used objective assessments include circumference and volume measurement, bioimpedance for detection of fluid state and all kinds of lymphatic system imaging techniques.

Application of fiberoptic endoscopic evaluation of swallowing (FEES) can accurately evaluate the static and dynamic anatomical structure of pharynx and larynx, the feeling of pharynx and larynx, secretion level, aspiration, residue and other important swallowing evaluation indexes, which is important for swallowing treatment and valuable for diagnosis of dysphagia.

As the manual muscle testing is not sensitive enough to reflect the change of muscle strength, more and more people begin to use isokinetic dynamometry and handheld dynamometer for quantitative tests of muscle strength measurement. This paper briefly introduced the history of clinical approaches of muscle strength measurement, compared the advantages and disadvantages of various quantitative muscle strength testing, on which the specific techniques of clinical muscle strength measurement were discussed.

After retrieving the databases, as well as the official websites of institutes and administrations of physiotherapists, the qualifications, working conditions and career development in different countries, such as United States, Canada, Australia, New Zealand, England, Ireland and South Africa, were investigated and analyzed, which may give some implication for the improvement of physiotherapists system in China.

Embodied cognition is an important research direction in current psycholinguistics. Perceptual symbols theory, indexical hypothesis, immersed experiencer framework, symbol interdependency hypothesis and mirror neuron system are important research achievements of embodied cognition in the field of language, which may light a way for the further development of speech therapy.

Motor dysfunction seriously affects the quality of life in stroke patients. Virtual reality, as a new strategy of rehabilitation, can be used to improve the range of motion of joint, movement accuracy, balance and gait, and so on, in stroke patients.

This paper summarized researches about the factors that influenced the measurement of hand grip, including equipments, ethnics,genders, ages, morphological parameters, handedness, occupation, grip width, body posture and psychological factors. All these are to be considered in studies of grip strength.

The language of hearing-impaired children is poorly developed. There is a lagging development of spoken language, which is manifested in pronunciation, grammar and pragmatics. Written language has difficulties in understanding and expression. Sign language develops normally, but it affects the spoken and written language of hearing-impaired children. This paper summarized the interventions, such as medicine, speech and family, according to the law of language development of children, in order to provide reference for the study and intervention of language development for hearing-impaired children.

To summarize the methods and results of human motion intention recognition based on the surface electromyography.

Literatures were retrieved and reviewed from the databases of PubMed, Web of Science, CNKI, Wanfang and VIP until December, 2020. The experimental researches about human motion intention recognition based on surface electromyography were summarized.

The methods of motion intention recognition were divided into three models: musculoskeletal model, traditional machine learning model and deep learning model.

It is difficult to fully estimate human motion intention using surface electromyography in a single way. More researches are needed to develop more accurate and real-time human motion intention recognition methods.

Traditional Chinese medicine (TCM) have unique efficacy and advantages for treating diseases of central nervous system. In recent years, some researches focused on neural stem cells and neurogenesis. The researches about TCM for influencing neural stem cells biological characteristics and common neurological diseases were reviewed.

Patients often suffered limb dysfunction after stroke. Upper limb and hand function recovered more slowly than lower limb, and became one of the research focuses in rehabilitation medicine. Timely and effective assessments were important to guide the rehabilitation treatment, evaluate the treatment efficacy and predict functional recovery of upper extremity and hand function. The assessment methods of upper limb and hand motor function included subjective evaluations and objective evaluations. The former included different kinds of scales, which involved assessment focusing on muscle, motor pattern, change of upper limb and hand function. While the latter contained biomechanics, neuroelectrophysiology, functional magnetic resonance imaging, upper limb robotic evaluation system and so on. Scales were proved to have good reliability and validity. But they could not show patients' function accurately because of the subjectivity, and the data could not be kept. Evaluation system with computer was applied in clinical practice more and more widely. In this review, we summarized the assessments on upper limb and hand motor function in patients after stroke.

To improve human cognition of sub-health condition by analyzing current situation of sub-health researches,the authors of this article reviewed the concept of sub-health,etiological factor,epidemiology,diagnostic code and other sides.

Mental stress may influence the autonomic nervous system (ANS) activity, and associate with the development of several chronic diseases. Mindfulness-based interventions, such as meditation, Yoga and Taiji Quan, are able to improve mental stress and ANS activity, which is probably related to its effects on the cortex to improve overall mental conditions and parasympathetic tone.

Low back pain (LBP) is one of the most common types of disability affecting individuals in Western countries, and the assessment of LBP-related disabilities represents a significant challenge. The disability assessment scales in LBP are commonly used in clinical diagnosis and treatment as well as evaluation system for clinical research, such as Oswestry Disability Index (ODI), Roland Morris Disability Questionnaire (RMDQ), and Quebec Back Pain Disability Scale (QBPDS). This article focused on the clinical applications, reliability and validity, strength and limitations of these scales, to help the clinical application and scientific research for the LBP disability scale.

Objective To investigate the development, hot spots and trends of event-related potentials for cognitive function research. Methods The literatures about application of event-related potentials in cognitive function research from 2011 to 2021 in CNKI and Web of Science core collection database were retrieved. The countries, authors, institutions, cited reference and keywords were extracted with CiteSpace to draw knowledge mapping. Results The most of researches came from the United States. For China, the author published the most researches was Zhan Xianghong, and the institute was the West China Mental Health Center of Sichuan University; the keywords such as P300 and depression were the most frequent, and researches focused on Alzheimer's disease, depression and schizophrenia, etc., which tended to use negative correlation changes of event-related potentials. Internationally, the author publishing the most researches was christian beste, and the institute was University of California, San Diego. The keywords such as attention and electroencephalograph were the most frequent, and researches focused on Alzheimer's disease and bipolar disorder, etc., which tended to focus on the P300 theta oscillation. Conclusion The application of event-related potential in cognitive function remains heat, to explore the cognitive dysfunction after various diseases.

Manual Muscle Testing is a widely used muscle power testing method in rehabilitation practice. Although it's a key content in rehabilitation medicine and rehabilitation therapy, there are some disagreements in lots of books introducing the development and rating system of it. This article reviewed the development of Manual Muscle Testing and different rating systems.

Spinal cord injury affects cerebral cortex in many respects,including morphology and gene expression of neurons,reorganization in function and structure,regional brain blood flow,expression of neurotrophic factor and its receptor.These changes may affect rehabilitation care and functional recovery of the patients with spinal cord injury.Therefore,studies targeting these changes are vital for our further understanding of the mechanisms of spinal cord injury and help to explore new therapies.

Spinal cord injury is a catastrophic injury causing lifelong severe disabilities, and poses a great burden to the individuals, families and society. In order to promote the standardization in treatment of traumatic spinal cord injury, the consensus on the evaluation, treatment and rehabilitation of traumatic spinal cord injury was suggested by experts, who came from authoritative multicenter in China. The expert consensus, which formed a standardization process from the first aid clinical treatment to rehabilitation of spinal cord injury, shall give a better practical guide for clinic and rehabilitation physicians.

Parkinson's disease is a common progressive neurodegenerative disorder among old people. Parkinson's disease model induced with 6-hydroxydopamine has been used to research pathology and medication of Parkinson's disease.